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Substrates | Biochemical

Biochemical

Sialic Acid Related Products

N-Acetyl-D-mannosamine Monohydrate [ManNAc]

Origin

Prepared by enzymatic hydrolysis of N-Acetylneuraminic Acid, and purified by crystallization.

Formula

C8H15NO6 , H2O (MW:239.2)

Appearance

White amorphous powder.

Purity

More than 99% by HPLC. Homogeneous by thin layer chromatographic analysis.

Storage

Stable when stored on desiccated condition at 5°C.

References

1) K. Hotta, M. Kurokawa and S. Isaka, Seikagaku (in Japanese), 45 (10), 911-915 (1973)
2) S. Blayer, J. M. Woodley, M. J. Dawson and M. D. Lilly, Biotechnology and Bioengineering, 66 (2), 131-136 (1999)

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
N-Acetyl-D-mannosamine, Monohydrate [ManNAc]
Prepared by enzymatic hydrolysis of N-acetylneuraminic acid, and purified by crystallization
5°C 05425-71 1 g 68 Buy Now
N-Acetyl-D-mannosamine, Monohydrate [ManNAc]
Prepared by enzymatic hydrolysis of N-acetylneuraminic acid, and purified by crystallization
5°C 05425-84 10 g 420 Buy Now

Sialic Acid Related Products

N-Acetylneuraminic Acid [NANA; Sialic Acid; NeuAc]

Origin

Prepared by enzymatic synthesis from N-Acetylglucosamine and Pyruvic Acid. Purified by ion-exchange column chromatography and crystallization.

Formula

C11H19NO9 (MW : 309.27)

Appearance

White crystalline powder.

Purity

More than 99% by colorimetric determination and HPLC.

Uses

Authentic specimen of the highest purity, substrate for NANA Aldolase and starting material for preparing NANA derivatives.

Storage

Stable for one year when stored on desiccated condition at 5°C.

References

1) Y. Uchida, Y. Tsukada and T. Sugimori, Biochim. Biophys. Acta., 350, 425 (1974)
2) I. Maru, J. Ohnishi, Y. Ohta, and Y. Tsukada, Carbohydr. Res., 306, 575 (1998)
3) Y. Uchida, Y. Tsukada and T. Sugimori, J. Biochem., 82, 1425 (1977)
4) L. Warren, J. Biol. Chem., 234, 1971 (1959)
5) J. T. Cassidy, G. W. Jourdian and S. Roseman, J. Biol. Chem., 240, 3501 (1965)
6) H. Araki and M. Yamada, Method of Enzymatic Analysis,VI, 80 (1984)

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
N-Acetylneuraminic acid (Enzymation) [NANA ; Sialic acid ; NeuAc] 5°C 08371-36 10g 260 Buy Now
N-Acetylneuraminic acid (Enzymation) [NANA ; Sialic acid ; NeuAc] 5°C 08371-94 100g 2,200 Buy Now

Sialic Acid Related Products

N-Acetylneuraminic Acid Oligomers Sodium Salt [DP2-DP6]

Origin

Prepared by hydrolysis of Colominic Acid.

Formula

dimer (DP2) C22H34N2O17Na2 (MW : 644.50)
trimer (DP3) C33H50N3O25Na3 (MW : 957.73)
tetramer (DP4) C44H66N4O33Na4 (MW : 1270.97)
pentamer (DP5) C55H82N5O41Na5 (MW : 1584.21)
hexamer (DP6) C66H98N6O49Na6 (MW : 1897.45)

Appearance

White amorphous powder , lyophilized

Purity

More than 95% by HPLC

Storage

Store below -20°C

Package

DP2 : 10 mg , 100 mg
DP3 ~ 6 : each 5 mg , 25 mg

Oligomer Kit

N-Acetylneuraminic Acid 10 mg
DP2, DP3, DP4, DP5, DP6 each 1 mg

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
N-Acetylneuraminic acid, dimer(α,2 → 8) [DP2] -20°C 00640-04 10 mg 48 Buy Now
N-Acetylneuraminic acid, dimer(α,2 → 8) [DP2] -20°C 00640-46 100 mg 210 Buy Now
N-Acetylneuraminic acid, trimer(α,2 → 8) [DP3] -20°C 00641-94 5 mg 50 Buy Now
N-Acetylneuraminic acid, trimer(α,2 → 8) [DP3] -20°C 00641-52 25 mg 220 Buy Now
N-Acetylneuraminic acid, tetramer(α,2 → 8) [DP4] -20°C 00642-84 5 mg 100 Buy Now
N-Acetylneuraminic acid, tetramer(α,2 → 8) [DP4] -20°C 00642-42 25 mg 310 Buy Now
N-Acetylneuraminic acid, pentamer(α,2 → 8) [DP5] -20°C 00643-74 5 mg 200 Buy Now
N-Acetylneuraminic acid, pentamer(α,2 → 8) [DP5] -20°C 00643-32 25 mg 620 Buy Now
N-Acetylneuraminic acid, hexamer(α,2 → 8) [DP6] -20°C 00644-64 5 mg 440 Buy Now
N-Acetylneuraminic acid, hexamer(α,2 → 8) [DP6] -20°C 00644-22 25 mg 1,200 Buy Now
N-Acetylneuraminic acid, oligomer(α,2 → 8) kit -20°C 00645-70 1 kit 290 Buy Now

Sialic Acid Related Products

N-Acetylneuraminyl-alpha(2-6)-lactose [6'-Sialyllactose]

Origin

Prepared by enzymatic synthesis from N-Acetylneuraminic Acid and Lactose.1)

Formula

C23H39NO19 (MW : 633.55)

Appearance

White amorphous powder.

Purity

More than 98% by HPLC. Homogeneous by thin layer chromatographic analysis.

Storage

Stable when stored on desiccated condition at 5°C.

References

1) I. Maru, Y. Ohta, K. Okamoto, S. Suzuki, K. Kakehi, and Y. Tsukada, Biosci. Biotech. Biochim., 56, 1557 (1992)
2) L. Svennerholm, Biochim. Biophys. Acta,24, 604 (1957)

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
N-Acetylneuraminyl-α (2 → 6)-lactose [6' -Sialyllactose] 5°C 00637-51 1 mg 240 Buy Now

Sialic Acid Related Products

Colominic Acid Sodium Salt

Origin

Colominic Acid, a homopolymer of N-Acetylneuraminic Acid (NANA) with (2 → 8) ketosidic linkages, is produced by special strains of Escherichia coli possessing K1 antigen.1)

Appearance

White amorphous powder.

Purity

More than 98% as NANA (Na salt).

Molecular weight

Approx. 30,000 Da (DPs ca. 100)

Uses

Substrate for Neuraminidase and starting material for preparing Sialic Acid derivatives.

Storage

Stable for one year or more when stored on desiccated condition at 5°C.

References

1) Y. Uchida, Y. Tsukada and T. Sugimori, Agric.Biol. Chem., 37, 2105 (1973)
2) J. T. Cassidy, G. W. Jourdian and S. Roseman, J. Biol. Chem., 240, 3501 (1965)
3) L. Svennerholm, Biochim. Biophys. Acta, 24, 604 (1957)
4) Y. Uchida, Y. Tsukada and T. Sugimori, J. Biochem., 82, 1425 (1977)
5) L. Warren, J. Biol. Chem., 234, 1971 (1959)

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
Colominic acid, Sodium salt 5°C 09324-71 1 g 200 Buy Now

Sialic Acid Related Products

Cytidine-5'-monophospho-N-acetylneuraminic Acid Disodium Salt [CMP-Neu5Ac2, Na]

Origin

Prepared by enzymatic synthesis from N-Acetylneuraminic Acid and CTP. Purified by ion-exchange column chromatography and lyophilization.

Formula

C20H29N4O16PNa2 (MW : 658)

Appearance

White lyophilized powder.

Purity

More than 97% by HPLC.

Storage

Stable when stored on desiccated condition below -20°C.

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
Cytidine-5'-monophospho-N-acetylneuraminic acid, Disodium salt [CMP -Neu5Ac·2NA] -20°C 10432-24 10 mg 92 Buy Now

Sialic Acid Related Products

2,3-Dehydro-2-deoxy-N-acetylneuraminic Acid [NeuAc2en; NeuNAc2en; Neu5Ac2en]

Origin

Prepared by chemical synthesis from N-acetylneuraminic acid.
Purified by column chromatography and crystallization.

Formula

C11H17NO8 ( MW : 291.25 )

Appearance

White crystalline powder.

Purity

More than 95% by HPLC.

Uses

Neuraminidase (sialidase) inhibitor.

Storage

Stable when stored on desiccated condition at -20°C.

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
[NeuAc2en ; NeuNAc2en ; Neu5Ac2en]
-20°C 05457-74 5 mg 150 Buy Now
2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
[NeuAc2en ; NeuNAc2en ; Neu5Ac2en]
-20°C 05457-32 25 mg 450 Buy Now

Sialic Acid Related Products

N-Glycolylneuraminic Acid [NeuGc; Neu5Gc; NeuNGc]

Origin

Prepared by chemo-enzymatic synthesis from glucosamine and pyruvic acid.

Formula

C11H19NO10 ( MW : 325.27 )

Appearance

White crystalline powder.

Purity

More than 98% by HPLC.

Storage

Stable when stored on desiccated condition below -20°C.

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
N-Glycolylneuraminic acid [NeuGc ; Neu5Gc ; NeuNGc] -20°C 05435-96 10 mg 320 Buy Now
N-Glycolylneuraminic acid [NeuGc ; Neu5Gc ; NeuNGc] -20°C 05435-54 50 mg 980 Buy Now

Sialic Acid Related Products

4-Methylumbelliferyl-N-acetyl-α-D-neuraminic Acid Ammonium Salt [4MU-NANA]

Formula

C21H28N2O11 (MW : 484.46)

Appearance

White crystalline powder, lyophilized.

Purity

More than 98% (Enzyme assay)

Storage

Store below -20°C. When kept below -20°C, the product is fairly stable even in solution. However, it is unstable in acidic solution. When 4-Methylumbelliferone is released because of decomposition during preservation, it can be removed by extraction with Ethyl Acetate for purification.

References

1) R. W. Myers, R. T. Lee, Y. C. Lee, G. H. Thomas, L. W. Reynolds and Y. Uchida, Anal. Biochem., 101, 166(1980)

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid, Ammonium salt [4-MU-NANA] -20°C 23229-91 1 mg 42 Buy Now
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid, Ammonium salt [4-MU-NANA] -20°C 23229-04 5 mg 115 Buy Now

Others

Uridine-5'-diphosphoglucose Disodium Salt

Formula

C15H22N2O17P2Na2 (MW : 610.3)

Appearance

White crystalline powder.

Purity

More than 98% (Moisture : approx. 7%)

Storage

Stable when stored on desiccated condition at 5°C.

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
Uridine-5'-diphosphoglucose, Disodium salt 5°C 36001-64 100 mg 45 Buy Now
Uridine-5'-diphosphoglucose, Disodium salt 5°C 36001-51 1 g 250 Buy Now

Others

Uridine-5'-diphosphoglucuronic acid, Trisodium salt

Formula

C15H19N2O18P2Na3 (MW : 646.3)

Appearance

White crystalline powder.

Purity

More than 98% (Moisture : approx. 12%)

Storage

Stable when stored on desiccated condition at 5 °C

Ordering information

Product Storage Cat.No. Quantity Price(US$)  
Uridine-5'-diphosphoglucuronic acid, Trisodium salt 5°C 36002-54 100 mg 105 Buy Now
Uridine-5'-diphosphoglucuronic acid, Trisodium salt 5°C 36002-41 1 g 740 Buy Now
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