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COSMOSIL πNAP

Specialty for Structual Isomers / π-π interaction, excellent selectivity for unsaturated compounds

Separation of unsaturated compounds on conventional reversed phase columns such as C8 and C18 is often problematic. Phenyl stationary phases are commonly used for these compounds because they form π-π interactions and show different selectivity from conventional alkyl phases. However, the π-π interactions on phenyl stationary phases are moderate, and the separation for some unsaturated compounds are still insufficient.

COSMOSIL πNAP is a Reversed Phase HPLC Column with naphtylethyl group bonded silica packing material. The naphthylethyl group is composed of two fused aromatic rings and forms strong π-π interactions with unsaturated compounds. This column offers improved selectivity for structural isomers that exhibit differences in saturation.

COSMOSIL πNAP
Silica gel High purity porous spherical silica
Average particle size 2.5 µm 5 µm
Average pore size approx. 130 Å approx. 120Å
Specific surface area approx. 330m2/g approx. 300 m²/g
Stationary phase Naphtylethyl group Naphtylethyl group
Bonding type Monomeric Monomeric
Carbon content approx. 11% approx. 11%
Usable pH range 2 - 7.5 2 - 7.5

Figure 1. Comparison of π-π interactions

COSMOSIL πNAP shows stronger π-π interactions than phenyl columns

Figure 2. Separation of tolunitrile isomers

Figure 3. Separation of steroids

Figure 4. Separation of tocopherols

Poster Presentation

HPLC 2008
May 13-15, 2008
Baltimore, MD

piNAP
COSMOSIL πNAP (PDF)

Ordering Information

Analytical Column (Particle Size : 2.5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSIL 2.5πNAP Packed Column, 2.0 mm I.D. x 50 mm 06062-91 Waters type 1 pkg 780.00 Buy
COSMOSIL 2.5πNAP Packed Column, 2.0 mm I.D. x 75 mm 06051-31 Waters type 1 pkg 780.00 Buy
COSMOSIL 2.5πNAP Packed Column, 2.0 mm I.D. x 100 mm 06052-21 Waters type 1 pkg 780.00 Buy
COSMOSIL 2.5πNAP Packed Column, 3.0 mm I.D. x 50 mm 06054-01 Waters type 1 pkg 780.00 Buy
COSMOSIL 2.5πNAP Packed Column, 3.0 mm I.D. x 75 mm 06055-91 Waters type 1 pkg 780.00 Buy
COSMOSIL 2.5πNAP Packed Column, 3.0 mm I.D. x 100 mm 06057-71 Waters type 1 pkg 780.00 Buy
Analytical Column (Particle Size : 5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSIL πNAP Packed Column, 1.0 mm I.D. x 150 mm 08076-61 Waters type 1 pkg 750.00 Buy
COSMOSIL πNAP Packed Column, 1.0 mm I.D. x 250 mm 08077-51 Waters type 1 pkg 880.00 Buy
COSMOSIL πNAP Packed Column, 2.0 mm I.D. x 30 mm 08566-41 Waters type 1 pkg 500.00 Buy
COSMOSIL πNAP Packed Column, 2.0 mm I.D. x 50 mm 08567-31 Waters type 1 pkg 530.00 Buy
COSMOSIL πNAP Packed Column, 2.0 mm I.D. x 100 mm 08299-51 Waters type 1 pkg 610.00 Buy
COSMOSIL πNAP Packed Column, 2.0 mm I.D. x 150 mm 08078-41 Waters type 1 pkg 660.00 Buy
COSMOSIL πNAP Packed Column, 2.0 mm I.D. x 250 mm 08079-31 Waters type 1 pkg 780.00 Buy
COSMOSIL πNAP Packed Column, 3.0 mm I.D. x 150 mm 08080-91 Waters type 1 pkg 550.00 Buy
COSMOSIL πNAP Packed Column, 3.0 mm I.D. x 250 mm 08081-81 Waters type 1 pkg 700.00 Buy
COSMOSIL πNAP Packed Column, 4.6 mm I.D. x 50 mm 08083-61 Waters type 1 pkg 440.00 Buy
COSMOSIL πNAP Packed Column, 4.6 mm I.D. x 100 mm 08084-51 Waters type 1 pkg 520.00 Buy
COSMOSIL πNAP Packed Column, 4.6 mm I.D. x 150 mm 08085-41 Waters type 1 pkg 550.00 Buy
COSMOSIL πNAP Packed Column, 4.6 mm I.D. x 250 mm 08086-31 Waters type 1 pkg 700.00 Buy
Guard Column (Particle Size : 5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSIL πNAP Guard Column, 4.6 mm I.D. x 10 mm 08082-71 Waters type 1 pkg 260.00 Buy
COSMOSIL πNAP Guard Column, 10 mm I.D. x 20 mm 08087-21 Waters type 1 pkg 500.00 Buy
COSMOSIL πNAP Guard Column, 20 mm I.D. x 20 mm 08090-61 Waters type 1 pkg 1,080.00 Buy
COSMOSIL πNAP Guard Column, 20 mm I.D. x 50 mm 08091-51 Waters type 1 pkg 1,400.00 Buy
COSMOSIL πNAP Guard Column, 28 mm I.D. x 50 mm 08094-21 Waters type 1 pkg 3,400.00 Buy
Preparative Column (Particle Size : 5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSIL πNAP Packed Column, 10 mm I.D. x 150 mm 08088-11 Waters type 1 pkg 1,300.00 Buy
COSMOSIL πNAP Packed Column, 10 mm I.D. x 250 mm 08089-01 Waters type 1 pkg 1,760.00 Buy
COSMOSIL πNAP Packed Column, 20 mm I.D. x 150 mm 08092-41 Waters type 1 pkg 2,610.00 Buy
COSMOSIL πNAP Packed Column, 20 mm I.D. x 250 mm 08093-31 Waters type 1 pkg 3,530.00 Buy
COSMOSIL πNAP Packed Column, 28 mm I.D. x 250 mm 08095-11 Waters type 1 pkg 7,030.00 Buy