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COSMOCORE 2.6C18

Core-Shell Particle

Features

  • Ultra-high performance LC results with conventional HPLC equipment
  • Same number of theoretical plates as sub-2 µm columns with half the back pressure
  • Increased loading capacity
  • Excellent pH stability (1.5-10)

Core-shell particles consist of a nonporous core inside a porous shell. By using these core-shell particles, one can achieve sharper peaks compared to fully porous silica gel particles of the same diameter with half the back pressure.

 

COSMOCORE 2.6C18
Silica gel Core-shell type silica gel
Average particle size 2.6 µm
Core average diameter 1.6 µm
Average pore size approx. 90Å
Specific surface area approx. 150 m2/g
Stationary phase Octadecyl group
Bonding type Polymeric
Main interaction Hydrophobic interaction
Endcapping treatment Near-perfect treatment
Carbon content approx. 7%
Usable pH range 1.5 - 10
Maximum pressure 60 MPa
>> Click here to COSMOCORE Development Kit 

Same Performance and Lower Back Pressure Compared to Sub-2 mm Particles

COSMOCORE 2.6C18 maintains the same performance as sub-2 µm particles with half the back pressure.

Column: COSMOCORE 2.6C18 ... Core shell (2.6 µm)
Company A ... Fully porous (1.7 µm, C18)
Column size: 2.1 mmI.D. x 100 mm
Mobile phase: Acetonitrile : Water = 60 : 40
Temperature: 40°C
Detection: UV 254 nm
Sample: 1. Benzene
2. Toluene
3. Ethylbenzene
4. Propylbenzene
5. Butylbenzene
6. Amylbenzene
(conc. 2.0 mg/ml)
Injection vol.: 0.5 µl

Reduced Back Pressure and Faster Analyses

COSMOCORE 2.6C18 delivers performance equivalent to sub-2 µm particles at faster flow rate and analysis time while maintaining a lower back pressure. COSMOCORE can also be used in longer column size to gain additional resolution.

COSMOSIL 2.5πNAP 2.5 µm, 2.0 mm ID x 50 mm Company A, UPLC C18 2.0 µm, 2.0 mm ID x 50 mm  

Column size: 2.1 mmI.D. x 50 mm
Mobile phase: Acetonitrile : Water = 70 : 30
Temperature: 40°C
Sample: Amylbenzene

 

Higher Retention and Loading Capacity than Competitors' Core-Shell Columns

· Retention
COSMOCORE 2.6C18 features high retention and better separation compared to other core-shell columns.

Column size: 2.1 mmI.D. x 50 mm
Mobile phase: A: Acetonitrile : Water = 50 : 50
B: Acetonitrile : Water = 80 : 20
B conc. 0 → 100% (0-4 min.), 100% (4-5 min.)
Flow rate: 0.4 ml/min
Temperature: 40°C
Detection: UV 254 nm
Sample: 1. Benzene
2. Toluene
3. Ethylbenzene
4. Propylbenzene
5. Butylbenzene
6. Amylbenzene
(conc. 2.0 mg/ml)
Injection vol.: 5 µl

· Higher Loading Capacity
In general, core-shell particles have less surface area and less bonded phase than fully porous particles. COSMOCORE 2.6C18, however, with a large amount of bonded phase, exhibits both high retention and high loading capacity. When injecting 5-10 times more sample volumes in the trace component analysis, COSMOCORE minimizes peak splitting due to the sample over loading.

Column size: 2.1 mmI.D. x 50 mm
Mobile phase: A: Acetonitrile : Water = 50 : 50
B: Acetonitrile : Water = 80 : 20
B conc. 0 → 100% (0-4 min.), 100% (4-5 min.)
Flow rate: 0.4 ml/min
Temperature: 40°C
Detection: UV 254 nm
Sample: 1. Benzene
2. Toluene
3. Ethylbenzene
4. Propylbenzene
5. Butylbenzene
6. Amylbenzene
(conc. 2.0 mg/ml)
Injection vol.: 5 µl

Sharp Peaks with Many Types of Compounds

COSMOCORE 2.6C18 features a special endcapping treatment that effectively shields residual silanol groups, yielding sharp peaks for basic compounds and metal coordination complexes.

· Basic compounds

· Metal coordination complexes

Differences between lots

COSMOCORE 2.6C18 minimizes differences between lots, so you can use these columns with confidence.

Column size: 2.1 mmI.D. x 50 mm
Mobile phase: Basic compounds:
Acetonitrile : 20 mmol/l phosphate buffer (pH7.0) = 60 : 40
Metal coordination complexes:
Acetonitrile : 20 mmol/l phosphoric acid = 10 : 90
Flow rate: 0.4 ml/min
Temperature: 40°C
Detection: UV 254 nm
Sample: Basic compounds:
 1. Amitriptyline (0.2 mg/ml)
 2. Amylbenzene (2.0 mg/ml)
Metal coordination complexes:
 1. Oxine-copper (0.003 mg/ml)
 2. Caffeine (0.3 mg/ml)

Durability test

COSMOCORE 2.6C18 exhibits high durability. There is no significant deterioration in retention or peak shape after 1,000 injection of amitriptyline.

Column size: 2.1 mmI.D. x 50 mm
Mobile phase: A: 0.1% TFA : Water
B: 0.1% TFA : Acetonitrile
B conc. 5 → 90% (0-3 min.), 90 → 5% (3-3.01 min.), 5% (3.01 - 6 min.)
Flow rate: 0.4 ml/min
Temperature: 40°C
Detection: UV 236 nm
Sample: Amitriptyline (0.2 mg/ml)
Injection vol.: 1.0 µl

Excelent pH Stability

Under accelerated¬†pH 10.4, 40°C¬†stability test, COSMOCORE C18 column shows superior stability compared with other core shell C18 phases.

Column size: 2.1 mmI.D. x 100 mm
Mobile phase: 0.35% Ammonium hydroxide : Acetonitrile = 90 : 10 (pH 10.4)
Flow rate: 0.4 ml/min
Temperature: 40°C
Sample: Caffeine (0.05 mg/ml)
Inj. Vol.: 1.0 µl

Low bleed - Suitable for LC-MS

COSMOCORE 2.6C18 has low column bleed, and consequently low MS noise level.

Column size: 2.1 mmI.D. x 50 mm
Mobile phase: A: 0.1% Formic Acid
B: Acetonitrile
B conc. 5 → 100% (0-5 min.), 100% (5-10 min.),
100 → 5% (10-11 min.), 5% (11-17 min.)
Flow rate: 0.2 ml/min
Temperature: 40°C
Detection: MS (TIC (+), MW 50-1000)

Ordering Information

Column
Product Cat.No. Quantity Price(US$)  
COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 30mm 12632-31 1 pkg 570.00 Buy
COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 50mm 12631-41 1 pkg 580.00 Buy
COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 75mm 12630-51 1 pkg 630.00 Buy
COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 100mm 12614-71 1 pkg 690.00 Buy
COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 150mm 12612-91 1 pkg 740.00 Buy
COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 30mm 12611-01 1 pkg 570.00 Buy
COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 50mm 12609-51 1 pkg 580.00 Buy
COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 75mm 12608-61 1 pkg 630.00 Buy
COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 100mm 12607-71 1 pkg 690.00 Buy
COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 150mm 12602-21 1 pkg 740.00 Buy
COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 30mm 12601-31 1 pkg 570.00 Buy
COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 50mm 12600-41 1 pkg 580.00 Buy
COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 75mm 12599-91 1 pkg 630.00 Buy
COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 100mm 12598-01 1 pkg 690.00 Buy
COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 150mm 12597-11 1 pkg 740.00 Buy
COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 250mm 12596-21 1 pkg 840.00 Buy
Prefilter
Product Cat.No. Quantity Price(US$)  
U-Fil UHPLC-compatible prefilter 12571-31 1 pkg 160.00 Buy