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COSMOSIL CHiRAL Series

Immobilized Polysaccharide Derivative-Based Chiral Columns

  • Immobilized chiral selectors can withstand many different solvents
  • Sharpen peaks with 3 μm particles
  • Preparative separations with 5 μm particles
  • Equivalent performance to columns currently on the market
  • Competitive price

Conceptual Model

COSMOSIL CHiRAL Series

Immobilized Stationary Phase

High Resistance to Solvents 

The COSMOSIL CHiRAL series uses a chiral selector that is chemically bonded to the silica gel, which results in high resistance to solvents. Tetrahydrofuran (THF) strips coated selectors from the stationary phase, reducing theoretical plates to less than 1/5 in our experiment. However, the same selectors bonded to the silica withstood repeated injections of THF.

Usable Solvents

Due to its immobilized selectors, various solvents are usable with COSMOSIL CHiRAL. A wide variety of solvents increases your selectivity options.

Available in 3 μm Particles

Sharp Peaks

COSMOSIL CHiRAL columns are available in 3 μm particles, which yield sharper peaks than conventional 5 μm particles. Columns for preparative separations are available with 5 μm particles.

Moderate Backpressure

The COSMOSIL CHiRAL 3 series (3 μm particles) puts moderately higher pressure on the system compared to conventional 5 μm particles. This improves reproducibility for low-pressure solvents, such as hexane, that may otherwise cause pump irregularities. As shown in the figure below, increased 2-propanol concentration causes higher pressure. However, even at 50% (v/v), the pressure did not exceed 12 MPa. At the lowest concentration of 5% (v/v), the backpressure was 5.3 MPa. This range allows high flexibility in mobile phase composition and selectivity.

Equivalent Separation to Competitors’ Columns

The COSMOSIL CHiRAL 5 series (5 μm particles) is equivalent to other companies’ immobilized polysaccharide derivative-based chiral columns. 

Same Selectivity with Identical Chiral Selectors

The same chiral selector will yield similar separation patterns. In general, Enantiomers that can be separated on a coated selector can also be separated on an immobilized selector, and those that cannot be separated on one will not be separated on the other. 

Column Selection

COSMOSIL CHiRAL offers 3 different chiral selectors that, together, have a high probability of separating your sample. Of 28 samples in our test, 27 pairs of enantiomers were fully separated. For samples that do not separate easily with any column, please adjust the type and concentration of solvents in your mobile phase. 

Application Data

Ordering Information

Analytical Column (Particle Size : 3 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSILCHiRAL 3A Packed Column, 4.6mmI.D. x 150mm 15778-51 Waters type 1 pkg 1,600.00 Buy
COSMOSILCHiRAL 3A Packed Column, 4.6mmI.D. x 250mm 15779-41 Waters type 1 pkg 1,750.00 Buy
COSMOSILCHiRAL 3B Packed Column, 4.6mmI.D. x 150mm 15783-71 Waters type 1 pkg 1,600.00 Buy
COSMOSILCHiRAL 3B Packed Column, 4.6mmI.D. x 250mm 15784-61 Waters type 1 pkg 1,750.00 Buy
COSMOSILCHiRAL 3C Packed Column , 4.6mmI.D. x 150mm 15788-21 Waters type 1 pkg 1,600.00 Buy
COSMOSILCHiRAL 3C Packed Column, 4.6mmI.D. x 250mm 15789-11 Waters type 1 pkg 1,750.00 Buy
Analytical Column (Particle Size : 5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSILCHiRAL 5A Packed Column, 4.6mmI.D. x 250mm 15780-01 Waters type 1 pkg 1,600.00 Buy
COSMOSILCHiRAL 5B Packed Column, 4.6mmI.D. x 250mm 15785-51 Waters type 1 pkg 1,600.00 Buy
COSMOSILCHiRAL 5C Packed Column, 4.6mmI.D. x 250mm 15790-71 Waters type 1 pkg 1,600.00 Buy
Preparative Column (Particle Size : 5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSILCHiRAL 5A Packed Column, 10.0mm I.D. x 250mm 15781-91 Waters type 1 pkg 5,350.00 Buy
COSMOSILCHiRAL 5A Packed Column , 20.0mm I.D. x 250mm 15782-81 Waters type 1 pkg 10,650.00 Buy
COSMOSILCHiRAL 5B Packed Column, 10.0mm I.D. x 250mm 15786-41 Waters type 1 pkg 5,350.00 Buy
COSMOSILCHiRAL 5B Packed Column, 20.0mm I.D. x 250mm 15787-31 Waters type 1 pkg 10,650.00 Buy
COSMOSILCHiRAL 5C Packed Column, 10.0mm I.D. x 250mm 15791-61 Waters type 1 pkg 5,350.00 Buy
COSMOSILCHiRAL 5C Packed Column, 20.0mm I.D. x 250mm 15792-51 Waters type 1 pkg 10,650.00 Buy