Nacalai USA - Innovations for Life Sciences

Subtotal: $0.00

View Cart

Biotinylated Kinases

Biotinylated kinases are now available from Carna Biosciences. These important reagents are best suited for the study of binding affinity and other kinase-molecule interactions on devices measuring Surface Plasmon Resonance (SPR), BioLayer Interferometry (BLI) and other similar values. They can also be utilized in homogenous proximity-based binding assays such as TR-FRET to interrogate inhibitor binding affinity, determine on-off rates, and measure binding kinetics.

The immobilization of target proteins onto sensor surfaces without impairing their structure and activity can be quite a challenging step in small molecule drug discovery.
Carna' s in-house single-site specifically biotinylated kinases can easily facilitate this immobilization and lead to the acquisition of real-time and accurate data for quick evaluation in your programs.

Advantages of Carna’s Biological Biotinylation

  • Kinases are labeled with a single biotin on the N-terminus
  • Easy-to-use - no additional labeling required
  • Native, catalytically active kinase domains
  • High quality human proteins produced in Baculovirus expression system (insect cells)
  • Stable Activity
  • Some kinases are available with pre-activation by ATP treatment, or unactivated (no ATP pre-treatment)

Advantages vs. Chemical Biotinylation

  • Single vs. multiple biotin molecules, which can possibly interfere with the ATP binding site following chemical biotinylation.
  • Preserved kinase activity and structure, which can be altered with chemical modification.
  • No additional purification is required (for excluding non-reacted biotin).

Ordering Information

Product Cat.No. Storage Quantity Price(US$)  
BTN - ABL(ABL1), Length: Full-length 08-401-20N-5 -80°C 5 µg N/A Inquire
BTN - ABL(ABL1), Length: Full-length 08-401-20N-10 -80°C 10 µg N/A Inquire
BTN - ACTR2B(ACVR2B), Length: Cytoplasmic domain 09-432-20N-5 -80°C 5 µg N/A Inquire
BTN - ACTR2B(ACVR2B), Length: Cytoplasmic domain 09-432-20N-10 -80°C 10 µg N/A Inquire
BTN - AKT1, Length: Catalytic domain 01-401-20N-5 -80°C 5 µg N/A Inquire
BTN - AKT1, Length: Catalytic domain 01-401-20N-10 -80°C 10 µg N/A Inquire
BTN - AKT2, Length: Catalytic domain 01-402-20N-5 -80°C 5 µg N/A Inquire
BTN - AKT2, Length: Catalytic domain 01-402-20N-10 -80°C 10 µg N/A Inquire
BTN - ALK, Length: Cytoplasmic domain 08-405-20N-5 -80°C 5 µg N/A Inquire
BTN - ALK, Length: Cytoplasmic domain 08-405-20N-10 -80°C 10 µg N/A Inquire
BTN - ALK[L1196M], Length: Cytoplasmic domain 08-429-20N-5 -80°C 5 µg N/A Inquire
BTN - ALK[L1196M], Length: Cytoplasmic domain 08-429-20N-10 -80°C 10 µg N/A Inquire
BTN - AurA(AURKA), Length: Full-length 05-401-20N-5 -80°C 5 µg N/A Inquire
BTN - AurA(AURKA), Length: Full-length 05-401-20N-10 -80°C 10 µg N/A Inquire
BTN-AurB(AURKB)/INCENP, Length: Full-length 05-402-21N-5 -80°C 5 µg N/A Inquire
BTN-AurB(AURKB)/INCENP, Length: Full-length 05-402-21N-10 -80°C 10 µg N/A Inquire
BTN - AXL, Length: Cytoplasmic domain 08-407-20N-5 -80°C 5 µg N/A Inquire
BTN - AXL, Length: Cytoplasmic domain 08-407-20N-10 -80°C 10 µg N/A Inquire
BTN - BMX, Length: Full-length 08-479-20N-5 -80°C 5 µg N/A Inquire
BTN - BMX, Length: Full-length 08-479-20N-10 -80°C 10 µg N/A Inquire
BTN - BTK, Length: Full-length 08-480-20N-5 -80°C 5 µg N/A Inquire
BTN - BTK, Length: Full-length 08-480-20N-10 -80°C 10 µg N/A Inquire
BTN-BTK[non-activated], Length: Full-length 08-480-23N-5 -80°C 5 µg N/A Inquire
BTN-BTK[non-activated], Length: Full-length 08-480-23N-10 -80°C 10 µg N/A Inquire
BTN - CHK1(CHEK1), Length: Full-length 02-417-20N-5 -80°C 5 µg N/A Inquire
BTN - CHK1(CHEK1), Length: Full-length 02-417-20N-10 -80°C 10 µg N/A Inquire
BTN - DDR2, Length: Cytoplasmic domain 08-414-20N-5 -80°C 5 µg N/A Inquire
BTN - DDR2, Length: Cytoplasmic domain 08-414-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKα(DGKA), Length: Full-length 12-401-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKα(DGKA), Length: Full-length 12-401-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKβ(DGKB), Length: Full-length 12-402-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKβ(DGKB), Length: Full-length 12-402-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKγ(DGKG), Length: Full-length 12-403-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKγ(DGKG), Length: Full-length 12-403-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKδ(DGKD), Length: Catalytic domain 12-404-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKδ(DGKD), Length: Catalytic domain 12-404-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKε(DGKE), Length: 48-567(end) 12-415-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKε(DGKE), Length: 48-567(end) 12-415-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKη(DGKH), Length: Catalytic domain 12-406-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKη(DGKH), Length: Catalytic domain 12-406-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKΙ(DGKI), Length: Full-length 12-407-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKΙ(DGKI), Length: Full-length 12-407-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKκ(DGKK), Length: Full-length 12-408-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKκ(DGKK), Length: Full-length 12-408-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKθ(DGKQ), Length: Full-length 12-409-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKθ(DGKQ), Length: Full-length 12-409-20N-10 -80°C 10 µg N/A Inquire
BTN-DGKζ(DGKZ), Length: Full-length 12-410-20N-5 -80°C 5 µg N/A Inquire
BTN-DGKζ(DGKZ), Length: Full-length 12-410-20N-10 -80°C 10 µg N/A Inquire
BTN - DLK(MAP3K12), Length: Catalytic domain 09-411-20N-5 -80°C 5 µg N/A Inquire
BTN - DLK(MAP3K12), Length: Catalytic domain 09-411-20N-10 -80°C 10 µg N/A Inquire
BTN - EGFR, Length: Cytoplasmic domain 08-415-20N-5 -80°C 5 µg N/A Inquire
BTN - EGFR, Length: Cytoplasmic domain 08-415-20N-10 -80°C 10 µg N/A Inquire
BTN - EGFR[T790M/L858R], Length: Cytoplasmic domain 08-410-20N-5 -80°C 5 µg N/A Inquire
BTN - EGFR[T790M/L858R], Length: Cytoplasmic domain 08-410-20N-10 -80°C 10 µg N/A Inquire
BTN - FAK(PTK2), Length: Truncated protein 08-437-20N-5 -80°C 5 µg N/A Inquire
BTN - FAK(PTK2), Length: Truncated protein 08-437-20N-10 -80°C 10 µg N/A Inquire
BTN - FGFR1, Length: Cytoplasmic domain 08-435-20N-5 -80°C 5 µg N/A Inquire
BTN - FGFR1, Length: Cytoplasmic domain 08-435-20N-10 -80°C 10 µg N/A Inquire
BTN-FGFR1 [non-activated], Length: Cytoplasmic domain 08-435-23N-5 -80°C 5 µg N/A Inquire
BTN-FGFR1 [non-activated], Length: Cytoplasmic domain 08-435-23N-10 -80°C 10 µg N/A Inquire
BTN - FGFR3, Length: Cytoplasmic domain 08-433-20N-5 -80°C 5 µg N/A Inquire
BTN - FGFR3, Length: Cytoplasmic domain 08-433-20N-10 -80°C 10 µg N/A Inquire
BTN - FGFR4, Length: Cytoplasmic domain 08-436-20N-5 -80°C 5 µg N/A Inquire
BTN - FGFR4, Length: Cytoplasmic domain 08-436-20N-10 -80°C 10 µg N/A Inquire
BTN - FLT3, Length: Cytoplasmic domain 08-454-20N-5 -80°C 5 µg N/A Inquire
BTN - FLT3, Length: Cytoplasmic domain 08-454-20N-10 -80°C 10 µg N/A Inquire
BTN - FMS(CSF1R), Length: Cytoplasmic domain 08-455-20N-5 -80°C 5 µg N/A Inquire
BTN - FMS(CSF1R), Length: Cytoplasmic domain 08-455-20N-10 -80°C 10 µg N/A Inquire
BTN - FYN[isoform a], Length: Full-length 08-468-20N-5 -80°C 5 µg N/A Inquire
BTN - FYN[isoform a], Length: Full-length 08-468-20N-10 -80°C 10 µg N/A Inquire
BTN - IGF1R, Length: Cytoplasmic domain 08-441-20N-5 -80°C 5 µg N/A Inquire
BTN - IGF1R, Length: Cytoplasmic domain 08-441-20N-10 -80°C 10 µg N/A Inquire
BTN - IKKb(IKBKB), Length: Truncated protein 05-484-20N-5 -80°C 5 µg N/A Inquire
BTN - IKKb(IKBKB), Length: Truncated protein 05-484-20N-10 -80°C 10 µg N/A Inquire
BTN - IKKα(CHUK), Length: Full-length 05-412-20N-5 -80°C 5 µg N/A Inquire
BTN - IKKα(CHUK), Length: Full-length 05-412-20N-10 -80°C 10 µg N/A Inquire
BTN - IKKα(CHUK)[inactive mutant], Length: Full-length 05-412-11-20N-5 -80°C 5 µg N/A Inquire
BTN - IKKα(CHUK)[inactive mutant], Length: Full-length 05-412-11-20N-10 -80°C 10 µg N/A Inquire
BTN - IRAK4, Length: Full-length 09-445-20N-5 -80°C 5 µg N/A Inquire
BTN - IRAK4, Length: Full-length 09-445-20N-10 -80°C 10 µg N/A Inquire
BTN - ITK, Length: Full-length 08-481-20N-5 -80°C 5 µg N/A Inquire
BTN - ITK, Length: Full-length 08-481-20N-10 -80°C 10 µg N/A Inquire
BTN - JAK1, Length: Catalytic domain 08-444-20N-5 -80°C 5 µg N/A Inquire
BTN - JAK1, Length: Catalytic domain 08-444-20N-10 -80°C 10 µg N/A Inquire
BTN - JAK2, Length: Catalytic domain 08-445-20N-5 -80°C 5 µg N/A Inquire
BTN - JAK2, Length: Catalytic domain 08-445-20N-10 -80°C 10 µg N/A Inquire
BTN - KDR(VEGFR2) , Length: Cytoplasmic domain 08-491-20N-5 -80°C 5 µg N/A Inquire
BTN - KDR(VEGFR2) , Length: Cytoplasmic domain 08-491-20N-10 -80°C 10 µg N/A Inquire
BTN - KIT, Length: Cytoplasmic domain 08-456-21N-5 -80°C 5 µg N/A Inquire
BTN - KIT, Length: Cytoplasmic domain 08-456-21N-10 -80°C 10 µg N/A Inquire
BTN - LCK, Length: Full-length 08-470-20N-5 -80°C 5 µg N/A Inquire
BTN - LCK, Length: Full-length 08-470-20N-10 -80°C 10 µg N/A Inquire
BTN - LYNa, Length: Full-length 08-471-20N-5 -80°C 5 µg N/A Inquire
BTN - LYNa, Length: Full-length 08-471-20N-10 -80°C 10 µg N/A Inquire
BTN - MAP2K1[inactive], Length: Full-length 07-441-10-20N-5 -80°C 5 µg N/A Inquire
BTN - MAP2K1[inactive], Length: Full-length 07-441-10-20N-10 -80°C 10 µg N/A Inquire
BTN - MAP3K5, Length: Catalytic domain 07-407-20N-5 -80°C 5 µg N/A Inquire
BTN - MAP3K5, Length: Catalytic domain 07-407-20N-10 -80°C 10 µg N/A Inquire
BTN - MET, Length: Cytoplasmic domain 08-451-20N-5 -80°C 5 µg N/A Inquire
BTN - MET, Length: Cytoplasmic domain 08-451-20N-10 -80°C 10 µg N/A Inquire
BTN - MNK1(MKNK1), Length: Full-length 02-445-20N-5 -80°C 5 µg N/A Inquire
BTN - MNK1(MKNK1), Length: Full-length 02-445-20N-10 -80°C 10 µg N/A Inquire
BTN - NEK9, Length: Truncated protein 05-433-20N-5 -80°C 5 µg N/A Inquire
BTN - NEK9, Length: Truncated protein 05-433-20N-10 -80°C 10 µg N/A Inquire
BTN - p38α(MAPK14), Length: Truncated protein 04-452-20N-5 -80°C 5 µg N/A Inquire
BTN - p38α(MAPK14), Length: Truncated protein 04-452-20N-10 -80°C 10 µg N/A Inquire
BTN - p38α(MAPK14)[inactive], Length: Truncated protein 04-452-10-20N-5 -80°C 5 µg N/A Inquire
BTN - p38α(MAPK14)[inactive], Length: Truncated protein 04-452-10-20N-10 -80°C 10 µg N/A Inquire
BTN - PAK4, Length: Full-length 07-426-20N-5 -80°C 5 µg N/A Inquire
BTN - PAK4, Length: Full-length 07-426-20N-10 -80°C 10 µg N/A Inquire
BTN - PIK3CA/PIK3R1, Length: Full-length 11-401-20N-5 -80°C 5 µg N/A Inquire
BTN - PIK3CA/PIK3R1, Length: Full-length 11-401-20N-10 -80°C 10 µg N/A Inquire
BTN-PIK3CB/PIK3R1, Length: Full-length 11-402-20N-5 -80°C 5 µg N/A Inquire
BTN-PIK3CB/PIK3R1, Length: Full-length 11-402-20N-10 -80°C 10 µg N/A Inquire
BTN-PIK3CD/PIK3R1, Length: Full-length 11-403-20N-5 -80°C 5 µg N/A Inquire
BTN-PIK3CD/PIK3R1, Length: Full-length 11-403-20N-10 -80°C 10 µg N/A Inquire
BTN-PIK3CG, Length: Full-length 11-404-20N-5 -80°C 5 µg N/A Inquire
BTN-PIK3CG, Length: Full-length 11-404-20N-10 -80°C 10 µg N/A Inquire
BTN - PKCη(PRKCH), Length: Full-length 01-438-20N-5 -80°C 5 µg N/A Inquire
BTN - PKCη(PRKCH), Length: Full-length 01-438-20N-10 -80°C 10 µg N/A Inquire
BTN - PKN1 , Length: Full-length 01-444-20N-5 -80°C 5 µg N/A Inquire
BTN - PKN1 , Length: Full-length 01-444-20N-10 -80°C 10 µg N/A Inquire
BTN - PLK1, Length: Full-length 05-457-20N-5 -80°C 5 µg N/A Inquire
BTN - PLK1, Length: Full-length 05-457-20N-10 -80°C 10 µg N/A Inquire
BTN - PYK2(PTK2B), Length: Full-length 08-438-20N-5 -80°C 5 µg N/A Inquire
BTN - PYK2(PTK2B), Length: Full-length 08-438-20N-10 -80°C 10 µg N/A Inquire
BTN - RET, Length: Cytoplasmic domain 08-459-20N-5 -80°C 5 µg N/A Inquire
BTN - RET, Length: Cytoplasmic domain 08-459-20N-10 -80°C 10 µg N/A Inquire
BTN - ROCK1, Length: Catalytic domain 01-409-20N-5 -80°C 5 µg N/A Inquire
BTN - ROCK1, Length: Catalytic domain 01-409-20N-10 -80°C 10 µg N/A Inquire
BTN - SPHK1, Length: Full-length 11-405-20N-5 -80°C 5 µg N/A Inquire
BTN - SPHK1, Length: Full-length 11-405-20N-10 -80°C 10 µg N/A Inquire
BTN - SPHK2, Length: Full-length 11-406-20N-5 -80°C 5 µg N/A Inquire
BTN - SPHK2, Length: Full-length 11-406-20N-10 -80°C 10 µg N/A Inquire
BTN - SRC, Length: Full-length 08-473-20N-5 -80°C 5 µg N/A Inquire
BTN - SRC, Length: Full-length 08-473-20N-10 -80°C 10 µg N/A Inquire
BTN - SRPK1, Length: Full-length 04-460-20N-5 -80°C 5 µg N/A Inquire
BTN - SRPK1, Length: Full-length 04-460-20N-10 -80°C 10 µg N/A Inquire
BTN - SYK, Length: Full-length 08-476-20N-5 -80°C 5 µg N/A Inquire
BTN - SYK, Length: Full-length 08-476-20N-10 -80°C 10 µg N/A Inquire
BTN-SYK[non-activated], Length: Full-length 08-476-23N-5 -80°C 5 µg N/A Inquire
BTN-SYK[non-activated], Length: Full-length 08-476-23N-10 -80°C 10 µg N/A Inquire
BTN-TAK1-TAB1(MAP3K7), Length: Fused protein 09-419-21C-5 -80°C 5 µg N/A Inquire
BTN-TAK1-TAB1(MAP3K7), Length: Fused protein 09-419-21C-10 -80°C 10 µg N/A Inquire
BTN - TGFβR1(TGFBR1), Length: Catalytic domain 09-441-20N-5 -80°C 5 µg N/A Inquire
BTN - TGFβR1(TGFBR1), Length: Catalytic domain 09-441-20N-10 -80°C 10 µg N/A Inquire
BTN - TIE2, Length: Cytoplasmic domain 08-485-20N-5 -80°C 5 µg N/A Inquire
BTN - TIE2, Length: Cytoplasmic domain 08-485-20N-10 -80°C 10 µg N/A Inquire
BTN - TNIK, Length: Catalytic domain 07-438-20N-5 -80°C 5 µg N/A Inquire
BTN - TNIK, Length: Catalytic domain 07-438-20N-10 -80°C 10 µg N/A Inquire
BTN - TRKA(NTRK1), Length: Cytoplasmic domain 08-486-20N-5 -80°C 5 µg N/A Inquire
BTN - TRKA(NTRK1), Length: Cytoplasmic domain 08-486-20N-10 -80°C 10 µg N/A Inquire
BTN-TRKA(NTRK1)[non-activated] , Length: Cytoplasmic domain 08-486-23N-5 -80°C 5 µg N/A Inquire
BTN-TRKA(NTRK1)[non-activated] , Length: Cytoplasmic domain 08-486-23N-10 -80°C 10 µg N/A Inquire
BTN - TRKB(NTRK2), Length: Cytoplasmic domain 08-487-20N-5 -80°C 5 µg N/A Inquire
BTN - TRKB(NTRK2), Length: Cytoplasmic domain 08-487-20N-10 -80°C 10 µg N/A Inquire
BTN-TRKB(NTRK2)[non-activated], Length: Cytoplasmic domain 08-487-23N-5 -80°C 5 µg N/A Inquire
BTN-TRKB(NTRK2)[non-activated], Length: Cytoplasmic domain 08-487-23N-10 -80°C 10 µg N/A Inquire
BTN - TRKC(NTRK3), Length: Catalytic domain 08-497-20N-5 -80°C 5 µg N/A Inquire
BTN - TRKC(NTRK3), Length: Catalytic domain 08-497-20N-10 -80°C 10 µg N/A Inquire
BTN - TYK2, Length: Catalytic domain 08-447-20N-5 -80°C 5 µg N/A Inquire
BTN - TYK2, Length: Catalytic domain 08-447-20N-10 -80°C 10 µg N/A Inquire
BTN - WNK1, Length: Catalytic domain 05-479-20N-5 -80°C 5 µg N/A Inquire
BTN - WNK1, Length: Catalytic domain 05-479-20N-10 -80°C 10 µg N/A Inquire
BTN - WNK4, Length: Catalytic domain 05-482-20N-5 -80°C 5 µg N/A Inquire
BTN - WNK4, Length: Catalytic domain 05-482-20N-10 -80°C 10 µg N/A Inquire