Labeling Reagent for LC-MS
L-FDVDA (1-Fluoro-2,4-dinitrophenyl-5-L-valine-N,N-dimethylethylenediamine-amide)
This product is a red to red-yellow crystal or powder that dissolves in acetone. It is a labeling reagent for amino groups and includes a chiral carbon, enabling the separation of labeled amino acids with a C18 or other achiral column (Figure. 1). As the reagent itself is more easily ionizable compared to conventional products, higher sensitivity with LC-MS can be achieved (Figure. 2), and it is suitable for analyzing trace amounts of peptides.
Figure. 1: Chiral separations of L-FDVDA-labeled amino acids
Figure. 1: Chiral separations of L-FDVDA-labeled amino acids
Figure 2. Comparison of detection sensitivity using LC-MS
Figure. 2: Comparison of detection sensitivity using LC-MS
Data provided by Dr. Takefumi Kuranaga, Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
Reference
Ordering Information
| Product | Formula = M.W. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| L-FDVDA (1-Fluoro-2,4-dinitrophenyl-5-L-valine-N,N-dimethylethylenediamine-amide) | C15H22N5O5F = 371.36 | 98.0% or more (HPLC) | 4℃ | 20363-24 | 50 mg | 200.00 | Buy |
The labeling reagent ispatented by Kyoto University. Nacalai Tesque, Inc. produces and distributes this product
under license.