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COSMOSIL Cholester

Specialty for Structual Isomers / Hydrophobic interaction and planarity selectivity

COSMOSIL Cholester is a new silica based RP column which employs a cholestery bonded phase. Cholester provides enhanced selectivity over traditional C18 materials and greater performance in separating isomers or other closely related compounds. Cholester is ideal for method development and serves as an excellent alternative to traditional C18 columns.

 

COSMOSIL Cholester
Silicagel high purity porous spherical silica
Average particle size 2.5µm 5µm
Average pore size approx. 130Å approx. 120Å
Specific surface area approx. 330m2/g approx. 300m2/g
Stationary phase Monomeric Cholesteryl group Monomeric Cholesteryl group
End capping treatment near-perfect treatment near-perfect treatment
Carbon content approx. 21% approx. 20%

Basic Nature

Separation of Alkylbenzene (comparison with Hydrophobicity)
Cholester provides the same hydrophobicity as ODS and C30 columns.

Planarity Selectivity (Planarity : o-Terphenyl < Triphenylene)
Cholester shows greater planarity selectivity.

Application: Aryl Halides

Characteristics of separation
Aryl Halides (Relative strengths of nucleophiles : Methyl < Chlorine < Bromine)
Cholester is more selective for Aryl Halides.

Planarity Selectivity

Planarity Selectivity (Planarity : o-Terphenyl < Triphenylene)
Cholester shows greater planarity selectivity.

Application: Steroids

Steroids like D Vitamins
Cholesteryl bonded groups are very rigid structures and offer improved separation of compounds that are difficult to analyze with alkyl group bonded materials.

Application: Diasteromers

Diasteromers like Stilbenes
Cholester offers improved resolution of geometric isomers.

Application: Position isomers

Position isomers like Chloroacetophenones and Terphenyls
Generally isomers of disubstituted benzene are difficult to separate with C18 because their structual and polar characteristics are veryb similar. In these cases COSMOSIL Cholester works very well.

Application: Geometric isomers

COSMOSIL Cholester offers improved resolution of geometric isomers.

Poster Presentation

HPLC 2007 (PDF)
June 17-21, 2007
Ghent, Belgium

Ordering Information

Analytical Column (Particle Size : 2.5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSIL 2.5 Cholester Packed Column, 2.0 mm I.D. x 50 mm 09000-01 Waters type 1 pkg 710.00 Buy
COSMOSIL 2.5 Cholester Packed Column, 2.0 mm I.D. x 75 mm 09047-11 Waters type 1 pkg 710.00 Buy
COSMOSIL 2.5 Cholester Packed Column, 2.0 mm I.D. x 100 mm 09048-01 Waters type 1 pkg 710.00 Buy
COSMOSIL 2.5 Cholester Packed Column, 3.0 mm I.D. x 50 mm 09049-91 Waters type 1 pkg 710.00 Buy
COSMOSIL 2.5 Cholester Packed Column, 3.0 mm I.D. x 75 mm 09050-51 Waters type 1 pkg 710.00 Buy
COSMOSIL 2.5 Cholester Packed Column, 3.0 mm I.D. x 100 mm 09051-41 Waters type 1 pkg 710.00 Buy
COSMOSIL 2.5 Cholester Packed Column, 3.0 mm I.D. x 150 mm 07099-01 Waters type 1 pkg 820.00 Buy
Analytical Column (Particle Size : 5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSIL Cholester Packed Column, 1.0 mm I.D. x 150 mm 05968-71 Waters type 1 pkg 450.00 Buy
COSMOSIL Cholester Packed Column, 1.0 mm I.D. x 250 mm 05969-61 Waters type 1 pkg 490.00 Buy
COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 30 mm 08565-51 Waters type 1 pkg 450.00 Buy
COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 50 mm 06352-91 Waters type 1 pkg 530.00 Buy
COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 100 mm 06948-01 Waters type 1 pkg 480.00 Buy
COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 150 mm 05971-11 Waters type 1 pkg 450.00 Buy
COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 250 mm 05972-01 Waters type 1 pkg 490.00 Buy
COSMOSIL Cholester Packed Column, 3.0 mm I.D. x 150 mm 05973-91 Waters type 1 pkg 450.00 Buy
COSMOSIL Cholester Packed Column, 3.0 mm I.D. x 250 mm 05974-81 Waters type 1 pkg 490.00 Buy
COSMOSIL Cholester Packed Column, 4.6 mm I.D. x 50 mm 06359-21 Waters type 1 pkg 510.00 Buy
COSMOSIL Cholester Packed Column, 4.6 mm I.D. x 100 mm 06591-61 Waters type 1 pkg 480.00 Buy
COSMOSIL Cholester Packed Column, 4.6 mm I.D. x 150 mm 05976-61 Waters type 1 pkg 450.00 Buy
COSMOSIL Cholester Packed Column (3 Lots Set), 4.6 mm I.D. x 150 mm 07970-03 Waters type 3 pkg 1,350.00 Buy
COSMOSIL Cholester Packed Column, 4.6 mm I.D. x 250 mm 05977-51 Waters type 1 pkg 490.00 Buy
Guard Column (Particle Size : 5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSIL Cholester Guard Column, 4.6 mm I.D. x 10 mm 05975-71 Waters type 1 pkg 250.00 Buy
COSMOSIL Cholester Guard Column, 10.0 mm I.D. x 20 mm 05978-41 Waters type 1 pkg 450.00 Buy
COSMOSIL Cholester Guard Column, 20.0 mm I.D. x 20 mm 05980-91 Waters type 1 pkg 1,000.00 Buy
COSMOSIL Cholester Guard Column, 20.0 mm I.D. x 50 mm 05981-81 Waters type 1 pkg 1,300.00 Buy
COSMOSIL Cholester Guard Column, 28.0 mm I.D. x 50 mm 05983-61 Waters type 1 pkg 3,290.00 Buy
Preparative Column (Particle Size : 5 µm)
Product Cat.No. End-Fitting Quantity Price(US$)  
COSMOSIL Cholester Packed Column, 10.0 mm I.D. x 150 mm 08011-91 Waters type 1 pkg 950.00 Buy
COSMOSIL Cholester Packed Column, 10.0 mm I.D. x 250 mm 05979-31 Waters type 1 pkg 1,210.00 Buy
COSMOSIL Cholester Packed Column, 20.0 mm I.D. x 150 mm 06088-71 Waters type 1 pkg 1,910.00 Buy
COSMOSIL Cholester Packed Column, 20.0 mm I.D. x 250 mm 05982-71 Waters type 1 pkg 2,420.00 Buy
COSMOSIL Cholester Packed Column, 28.0 mm I.D. x 250 mm 05985-41 Waters type 1 pkg 5,510.00 Buy