Nacalai USA - Innovations for Life Sciences

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Linker beads

  1. K. Fujita et al.
    FPesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins
    Environmental Pollution 266 (2020) 115179

  2. A. Iwabuchi et al.
    Factors regulating the differential uptake of persistent organic pollutants in cucurbits and non-cucurbits
    Journal of Plant Physiology 245 (2020) 153094

  3. T. Saito et al.
    Nobiletin and related polymethoxylated flavones bind to and inhibit the nuclear export factor Exportin-1 in NK leukemia cell line KHYG-1
    Biochemical and Biophysical Research Communications 521 (2020) 457

  4. J. Goto et al.
    Uptake mechanisms of polychlorinated biphenyls in Cucurbita pepo via xylem sap containing major latex-like proteins.
    Environ. Exp. Bot., 162, 399(2019)

  5. Y. Yoshioka et al.
    Glabridin inhibits dexamethasone-induced muscle atrophy.
    Arch. Biochem. Biophys., 664, 157(2019)

  6. H. Ono et al.
    Ribosomal protein S3 regulates XIAP expression independently of the NF-κB pathway in breast cancer cells
    ONCOLOGY REPORTS, 38, 3205 (2017).

  7. M. Watanabe et al.
    The pleiotropic regulation of cyclin D1 by newly identified sesaminol-binding protein ANT2.
    Oncogenesis, 6, e311 (2017).

  8. T. Taniguchi et al.
    Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer.
    Cell Death Dis., 7, e2211 (2016).

  9. T. Furukawa et al.
    Precocene II, a Trichothecene Production Inhibitor, Binds to Voltage-Dependent Anion Channel and Increases the Superoxide Level in Mitochondria of Fusarium graminearum.
    PLOS ONE, DOI:10.137 (2015).

  10. T. Hosoi et al.
    Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress.
    EMBO Molecular Medicine, DOI: 10.1002 (2014).

  11. H. Inui et al.
    A major latex-like protein is a key factor in crop contamination by persistent organic pollutants.
    Plant Physiology, 161, 2128 (2013).

  12. Y. Iizumi et al.
    The Flavonoid Apigenin Downregulates CDK1 by DirectlyTargeting Ribosomal Protein S9.
    PLOS ONE, 8, e73219 (2013).

  13. K. Hotta et al.
    Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein.
    Mol. Pharmacol., 83, 930 (2013).

  14. Y. Ito et al.
    Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A.
    PLOS ONE, 7, e50481 (2012).

  15. ※Use by changing epoxy groups into the NHS groups
    M. Hiramoto et al.
    High-performance affinity chromatography method for identification of L-arginine interacting factors using magnetic nanobeads.
    Biomed. Chromatogr., 10, 606 (2009).

  16. Y. Masaike et al.
    Identification of Dynamin-2-mediated Endocytosis as a New Target of Osteoporosis Drugs, Bisphosphonates.
    Mol. Pharmacol., 77, 262 (2009).

  17. C. Kuramori et al.
    Mono-(2-ethylhexyl) phthalate Targets Glycogen Debranching Enzyme and Affects Glycogen Metabolism in Rat Testis.
    Toxicol. Sci., 109, 143 (2009).

  18. Y. Hase et al.
    Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm.
    Biochem. Biophys. Res. Commun., 366, 66 (2008).

  19. M. Hiramoto et al.
    High-performance affinity beads for identifying anti-NF-κB drug receptors.
    Methods Enzymol., 353, 81 (2002).

  20. ※Use by changing epoxy groups into the NH2 groups
    N. Shimizu et al.
    High-performance affinity beads for identifying drug receptors.
    Nat. Biotechnol., 18, 877 (2000).

COOH beads

  1. Kobayashi, Hidetoshi, et al. "Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway." Endocrine Journal 69.5 (2022): 539-546.
  2. Nan Yagishita-Kyo et al.
    Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus
    Biochemical and Biophysical Research Communications 551 (2021) 54

  3. V. Gupta et al.
    Salicylic Acid Induces Mitochondrial Injury by Inhibiting Ferrochelatase Heme Biosynthesis Activity.
    Mol. Pharmacol., DOI:10.1124 (2013).

  4. ※Use by changing COOH groups into the NHS groups
    S. Karasawa et al.
    Vitamin K2 Covalently Binds to Bak and Induces Bak-Mediated Apoptosis.
    Mol. Pharmacol., 83, 613 (2013).

  5. A. Sandhu et al.
    Synthesis and applications of magnetic nanoparticles for biorecognition and point of care medical diagnostics.
    Nanotechnology, 21, 442001 (2010).

  6. C. Kuramori et al.
    Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus.
    Biochem. Biophys. Res. Commun., 379, 519 (2009).

  7. M. Suzuki et al.
    Development of a chemical screening system using aqueorin-fused protein.
    Biochem. Biophys. Res. Commun., 368, 600 (2008).

  8. ※Use by changing COOH groups into the NHS groups
    M. Yoshida et al.
    A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3- hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads.
    Mol. Pharmacol., 73, 987 (2008).

  9. H. Uga et al.
    A new mechanism of methotrexate action revealed by target screening with affinity beads.
    Mol. Pharmacol., 70, 1832 (2006).

  10. H. Hatori et al.
    FR225659-binding proteins: identification as serine/threonine protein phosphatase PP1 and PP2A using high-performance affinity beads.
    . Antibiot., 57, 456 (2004).

NH2 beads

  1. Y. Kabe et al.
    Glycyrrhizin derivatives suppress cancer chemoresistance by inhibiting progesterone receptor membrane component 1
    Cancers, 13, 3265 (2021)

  2. H. Tsugawa et al.
    Short-chain fatty acids bind to apoptosisassociated speck-like protein to activate inflammasome complex to prevent Salmonella infection
    PLoS Biol, 2020 18(9):e3000813

  3. J. Cho et al.
    L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells
    Communications Biology (2020) 3:497

  4. T. Ito et al.
    Molecular mechanisms of thalidomide and its derivatives
    Proc. Jpn. Acad., Ser. B 96 (2020)

  5. Y. Kabe et al.
    Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites
    npj Science of Food (2020) 4

  6. T. Asatsuma-Okumura el al.
    Molecular mechanisms of cereblon-based drugs.
    Pharmacology & Therapeutics, 202, 132(2019)

  7. M. Tera el al.
    Identification of a binding protein for sesamin and characterization of its roles in plant growth.
    Scientific Reports, 9, 8631(2019)

  8. H. Tan et al.
    Ursolic Acid Isolated from the Leaves of Loquat ( Eriobotrya japonica) Inhibited Osteoclast Differentiation through Targeting Exportin 5.
    J. Agric. Food Chem., 67, 3333(2019)

  9. Y. Aono et al.
    Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2.
    Biochem. Biophys. Res. Commun., 505, 1203 (2018).

  10. T. mori et al.
    Structural basis of thalidomide enantiomer binding to cereblon.
    Scientific Reports, 8, 1294 (2018).

  11. M. Boccitto et al.
    The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.
    Mar. Drugs, 15, 246 (2017).

  12. Y. kabe et al.
    Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.
    Nature Communications, 7:11030 (2016).

  13. P. P. Chamberlain et al.
    Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.
    Nat. Struct. Mol. Biol., 21, 803 (2014).

  14. A. Perez-Perarnau et al.
    A Trifluorinated Thiazoline Scaffold Leading to Pro-apoptotic Agents Targeting Prohibitins.
    Angew. Chem. Int. Ed., 53, 10150 (2014).

  15. T. Ito, H. Handa.
    Deciphering the mystery of thalidomide teratogenicity.
    Congenital Anomalies, 52, 1 (2012)

  16. J. Liu et al.
    Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms.
    Scientific Reports, 2, 905 (2012).

  17. N. Maekawa et al.
    High-performance affinity purification for identification of 15-deoxy-D12,14-PGJ2 interacting factors using magnetic nanobeads.
    Biomed. Chromatogr., 25, 466 (2011).

  18. T. Ito, H. Ando, H. Handa.
    Teratogenic effects of thalidomide:molecular mechanisms.
    Cell. Mol. Life Sci., 68,1569 (2011).

  19. T. Ito et al.
    Identification of a Primary Target of Thalidomide Teratogenicity.
    Science, 327, 1345 (2010).

  20. K. Kume et al.
    Role of N-end rule ubiquitin ligases UBR1 and UBR2 inregulating the leucine-mTOR signaling pathway.
    Genes Cells, 15, 339 (2010).

  21. ※Use by changing NH2 groups into the NHS groups
    K. Nishio et al.
    Development of novel magnetic nano-carriers for high-performantce affinity purification.
    Coll. Surf. B., 64, 162 (2008).

  22. ※Use by changing NH2 groups into the NHS groups
    E. Suzuki et al.
    Preparation of conophylline affinity nano-beads and identification of a target protein.
    Bioorg. Med. Chem., 17, 6185 (2009).

  23. M. Azuma et al.
    Adenine nucleotide translocator transports haem precursors into mitochondria.
    PLOS ONE, 3, e3070 (2008).

  24. M. Hasegawa et al.
    Affinity identification of delta-opioid receptors using latex nanoparticles.
    Bioorg. Med. Chem. Lett., 16, 158 (2006).

  25. Y. Kabe et al.
    Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier.
    J. Biol. Chem., 281, 31729 (2006).

  26. ※Use by changing NH2 groups into the NHS groups
    T. Zenkoh et al.
    Design and synthesis of a solid-supported FR225659 derivative for its receptor screening.
    Org. Lett., 6, 2477 (2004).

  27. ※Use by changing NH2 groups into the NHS groups
    D. Shima et al.
    Mechanism of H-8 inhibition of Cyclin-dependent kinase 9:study using inhibitor-immobilized matrices.
    Genes to Cells, 8, 215 (2003).

Streptavidin beads / Protein A beads / Protein G beads