mRNA and Oligonucleotides purification with chromatography

RNA based therapeutics represent a powerful new tool for gene therapy. In RNA production, impurities such as nucleotide triphosphates, abortive transcripts, and DNA template can affect down-stream applications by triggering immune responses...

Cat.No.: 12614-71, 22524-41, 21078-31, 21079-21, 21080-81, 21088-01, 19380-21, 20785-91, 21095-01, 19381-11, +2 more

HFIP for Nucleic Acid Analysis

For impurity analysis of oligonucleic acids using HPLC or LC-MS

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is frequently used as a mobile phase additive for analysis of oligonucleotides below 100 nucleotides (nt) and their impurities, due to the high sensitivity and separation it enables. However, there a...

Cat.No.: 22941-42