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COSMOSIL SL-II

Normal Phase

  • High purity silica gel (>99.99%) with specially treatment
  • Suitable for preparative separation
SL-II
USP code L3
Silica gel High purity porous spherical silica
Average particle size 3 µm, 5 µm, 15 µm
Average pore size approx. 120Å
Specific surface area approx. 300m2/g

Analysis of Acids and Amide without Ionic Additives

Column size: 4.6 mm I.D. x 250 mm
Mobile phase: Methanol : Hexane = 10 : 90
Flow rate: 1 ml/min
Temperature: 30°C
Detection: UV 254 nm, 0.5AUFS
Sample: 1. Benzoic Acid 4.0 µg
2. Salicylic Acid 6.0 µg
3. Salicylamide 4.0 µg

Comparison with Medium-pressure Columns

COSMOSIL SL-II offers sharper peak compared with packing materials for medium-pressure liquid chromatography and open chromatography.
Column 5SL-II A Company Cartridge
(30 µm silica gel)
B Company Cartridge
(60 µm silica gel)
Column Size 20 mm I.D. x 250 mm 26 mm I.D. x 104 mm 26 mm I.D. x 104 mm
Pressure 1.3 MPa 0.25 MPa 0.15 MPa
Chromatogram
Mobile phase: Ethanol : Hexane = 5 : 95
Flow rate: 10 ml/min
Temperature: Room Temperature
Detection: UV 254 nm
Sample: 1. p-Xylene 8.3 mg
2. Cinnamyl Alcohol 1.7 mg
3. p-Nitrobenzyl Alcohol 4.2 mg

Scaling Up from Analytical to Preparative Separation

COSMOSIL SL-II offers sharper peak compared with packing materials for medium-pressure liquid chromatography and open chromatography.
Step 1 Step 2 Step 3
Mobile phase is optimized by using 4.6 mm I.D. x 250 mm column Maximum load capacity is optimized by using 4.6 mm I.D. x 250 mm column Preparative separation by using 20 mm I.D. x 250 mm column
As mobile phase, highly soluble solvent for sample is suitable. Maximum injection volume 56 µl (28 mg) Maximum injection volume 1,050 µl (525 mg) (19 times higher than 4.6 mm I.D.)
Mobile phase: Ethyl Acetate : Hexane = 10 : 90
Flow rate: 4.6 mm I.D. : 1 ml/min
20 mm I.D. : 18.9 ml/min
Temperature: Room Temperature
Detection: UV 254 nm
Sample: 1.1-Naphthol
2.2-Naphthol

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COSMOSIL Application Search

COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size

Ordering Information

Product Cat.No. End-Fitting PKG Size Price(US$)  
COSMOSIL 3SL-II Packed Column (2.0 mm I.D. x 150 mm) 18282-41 Waters type 1 pkg 557.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 10 mm) 38059-61 Waters type 1 pkg 348.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 50 mm) 38060-21 Waters type 1 pkg 364.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 100 mm) 38061-11 Waters type 1 pkg 450.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 150 mm) 02266-51 Waters type 1 pkg 509.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 250 mm) 19400-51 Waters type 1 pkg 632.00 Buy
COSMOSIL 3SL-II Packed Column (6.0 mm I.D. x 100 mm) 09192-01 Waters type 1 pkg 840.00 Buy
COSMOSIL 5SL-II Packed Column (1.0 mm I.D. x 100 mm) 08978-51 Waters type 1 pkg 535.00 Buy
COSMOSIL 5SL-II Packed Column (2.0 mm I.D. x 150 mm) 19547-51 Waters type 1 pkg 514.00 Buy
COSMOSIL 5SL-II Packed Column (2.0 mm I.D. x 250 mm) 06945-31 Waters type 1 pkg 568.00 Buy
COSMOSIL 5SL-II Packed Column (3.0 mm I.D. x 150 mm) 07380-91 Waters type 1 pkg 428.00 Buy
COSMOSIL 5SL-II Packed Column (4.6 mm I.D. x 50 mm) 37999-81 Waters type 1 pkg 348.00 Buy
COSMOSIL 5SL-II Packed Column (4.6 mm I.D. x 100 mm) 38000-01 Waters type 1 pkg 471.00 Buy
COSMOSIL 5SL-II Packed Column (4.6 mm I.D. x 150 mm) 38001-91 Waters type 1 pkg 428.00 Buy
COSMOSIL 5SL-II Packed Column (4.6 mm I.D. x 250 mm) 38002-81 Waters type 1 pkg 471.00 Buy
COSMOSIL 5SL-II Packed Column (6.0 mm I.D. x 150 mm) 38003-71 Waters type 1 pkg 541.00 Buy
COSMOSIL 5SL-II Packed Column (6.0 mm I.D. x 250 mm) 38004-61 Waters type 1 pkg 696.00 Buy
COSMOSIL 5SL-II Packed Column (10.0 mm I.D. x 250 mm) 38005-51 Waters type 1 pkg 969.00 Buy
COSMOSIL 5SL-II Packed Column (20.0 mm I.D. x 150 mm) 04668-31 Waters type 1 pkg 1,819.00 Buy
COSMOSIL 5SL-II Packed Column (20.0 mm I.D. x 250 mm) 38006-41 Waters type 1 pkg 2,033.00 Buy
COSMOSIL 5SL-II Packed Column (28.0 mm I.D. x 250 mm) 34358-61 Waters type 1 pkg 4,066.00 Buy
COSMOSIL 15SL-II Packed Column (28.0 mm I.D. x 250 mm) 05893-41 Waters type 1 pkg 3,136.00 Buy
COSMOSIL 15SL-II Packed Column (50.0 mm I.D. x 250 mm) 05895-21 Waters type 1 pkg 4,965.00 Buy
COSMOSIL 15SL-II Packed Column (50.0 mm I.D. x 500 mm) 05896-11 Waters type 1 pkg 7,458.00 Buy
Guard Column
Product Cat.No. End-Fitting PKG Size Price(US$)  
COSMOSIL 5SL-II Guard Column (4.6 mm I.D. x 10 mm) 37997-01 Waters type 1 pkg 214.00 Buy
COSMOSIL 5SL-II Guard Column (10.0 mm I.D. x 20 mm) 37998-91 Waters type 1 pkg 370.00 Buy
COSMOSIL 5SL-II Guard Column (20.0 mm I.D. x 20 mm) 05874-91 Waters type 1 pkg 808.00 Buy
COSMOSIL 5SL-II Guard Column (20.0 mm I.D. x 50 mm) 05875-81 Waters type 1 pkg 1,054.00 Buy
COSMOSIL 5SL-II Guard Column (28.0 mm I.D. x 50 mm) 34359-51 Waters type 1 pkg 1,910.00 Buy
COSMOSIL 15SL-II Guard Column (28.0 mm I.D. x 50 mm) 05892-51 Waters type 1 pkg 1,755.00 Buy
COSMOSIL 15SL-II Guard Column (50.0 mm I.D. x 50 mm) 05894-31 Waters type 1 pkg 4,125.00 Buy