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COSMOSIL SL-II

Normal Phase

  • High purity silica gel (>99.99%) with specially treatment
  • Suitable for preparative separation
SL-II
USP code L3
Silica gel High purity porous spherical silica
Average particle size 3 µm, 5 µm, 15 µm
Average pore size approx. 120Å
Specific surface area approx. 300m2/g

Analysis of Acids and Amide without Ionic Additives

Column size: 4.6 mm I.D. x 250 mm
Mobile phase: Methanol : Hexane = 10 : 90
Flow rate: 1 ml/min
Temperature: 30°C
Detection: UV 254 nm, 0.5AUFS
Sample: 1. Benzoic Acid 4.0 µg
2. Salicylic Acid 6.0 µg
3. Salicylamide 4.0 µg

Comparison with Medium-pressure Columns

COSMOSIL SL-II offers sharper peak compared with packing materials for medium-pressure liquid chromatography and open chromatography.
Column 5SL-II A Company Cartridge
(30 µm silica gel)
B Company Cartridge
(60 µm silica gel)
Column Size 20 mm I.D. x 250 mm 26 mm I.D. x 104 mm 26 mm I.D. x 104 mm
Pressure 1.3 MPa 0.25 MPa 0.15 MPa
Chromatogram
Mobile phase: Ethanol : Hexane = 5 : 95
Flow rate: 10 ml/min
Temperature: Room Temperature
Detection: UV 254 nm
Sample: 1. p-Xylene 8.3 mg
2. Cinnamyl Alcohol 1.7 mg
3. p-Nitrobenzyl Alcohol 4.2 mg

Scaling Up from Analytical to Preparative Separation

COSMOSIL SL-II offers sharper peak compared with packing materials for medium-pressure liquid chromatography and open chromatography.
Step 1 Step 2 Step 3
Mobile phase is optimized by using 4.6 mm I.D. x 250 mm column Maximum load capacity is optimized by using 4.6 mm I.D. x 250 mm column Preparative separation by using 20 mm I.D. x 250 mm column
As mobile phase, highly soluble solvent for sample is suitable. Maximum injection volume 56 µl (28 mg) Maximum injection volume 1,050 µl (525 mg) (19 times higher than 4.6 mm I.D.)
Mobile phase: Ethyl Acetate : Hexane = 10 : 90
Flow rate: 4.6 mm I.D. : 1 ml/min
20 mm I.D. : 18.9 ml/min
Temperature: Room Temperature
Detection: UV 254 nm
Sample: 1.1-Naphthol
2.2-Naphthol

Downloads

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COSMOSIL Application Search

COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size

Ordering Information

Product Description Cat.No. PKG Size Price  
COSMOSIL 3SL-II Packed Column (2.0 mm I.D. x 150 mm) End-Fitting: Waters type
18282-41 1 pkg 557.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 10 mm) End-Fitting: Waters type
38059-61 1 pkg 348.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 50 mm) End-Fitting: Waters type
38060-21 1 pkg 364.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 100 mm) End-Fitting: Waters type
38061-11 1 pkg 450.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 150 mm) End-Fitting: Waters type
02266-51 1 pkg 509.00 Buy
COSMOSIL 3SL-II Packed Column (4.6 mm I.D. x 250 mm) End-Fitting: Waters type
19400-51 1 pkg 632.00 Buy
COSMOSIL 3SL-II Packed Column (6.0 mm I.D. x 100 mm) End-Fitting: Waters type
09192-01 1 pkg 840.00 Buy
COSMOSIL 5SL-II Packed Column (1.0 mm I.D. x 100 mm) End-Fitting: Waters type
08978-51 1 pkg 535.00 Buy
COSMOSIL 5SL-II Packed Column (2.0 mm I.D. x 150 mm) End-Fitting: Waters type
19547-51 1 pkg 514.00 Buy
COSMOSIL 5SL-II Packed Column (2.0 mm I.D. x 250 mm) End-Fitting: Waters type
06945-31 1 pkg 568.00 Buy
COSMOSIL 5SL-II Packed Column (3.0 mm I.D. x 150 mm) End-Fitting: Waters type
07380-91 1 pkg 428.00 Buy
COSMOSIL 5SL-II Packed Column (4.6 mm I.D. x 50 mm) End-Fitting: Waters type
37999-81 1 pkg 348.00 Buy
COSMOSIL 5SL-II Packed Column (4.6 mm I.D. x 100 mm) End-Fitting: Waters type
38000-01 1 pkg 471.00 Buy
COSMOSIL 5SL-II Packed Column (4.6 mm I.D. x 150 mm) End-Fitting: Waters type
38001-91 1 pkg 428.00 Buy
COSMOSIL 5SL-II Packed Column (4.6 mm I.D. x 250 mm) End-Fitting: Waters type
38002-81 1 pkg 471.00 Buy
COSMOSIL 5SL-II Packed Column (6.0 mm I.D. x 150 mm) End-Fitting: Waters type
38003-71 1 pkg 541.00 Buy
COSMOSIL 5SL-II Packed Column (6.0 mm I.D. x 250 mm) End-Fitting: Waters type
38004-61 1 pkg 696.00 Buy
COSMOSIL 5SL-II Packed Column (10.0 mm I.D. x 250 mm) End-Fitting: Waters type
38005-51 1 pkg 969.00 Buy
COSMOSIL 5SL-II Packed Column (20.0 mm I.D. x 150 mm) End-Fitting: Waters type
04668-31 1 pkg 1,819.00 Buy
COSMOSIL 5SL-II Packed Column (20.0 mm I.D. x 250 mm) End-Fitting: Waters type
38006-41 1 pkg 2,033.00 Buy
COSMOSIL 5SL-II Packed Column (28.0 mm I.D. x 250 mm) End-Fitting: Waters type
34358-61 1 pkg 4,066.00 Buy
COSMOSIL 15SL-II Packed Column (28.0 mm I.D. x 250 mm) End-Fitting: Waters type
05893-41 1 pkg 3,136.00 Buy
COSMOSIL 15SL-II Packed Column (50.0 mm I.D. x 250 mm) End-Fitting: Waters type
05895-21 1 pkg 4,965.00 Buy
COSMOSIL 15SL-II Packed Column (50.0 mm I.D. x 500 mm) End-Fitting: Waters type
05896-11 1 pkg 7,458.00 Buy
Guard Column
Product Description Cat.No. PKG Size Price  
COSMOSIL 5SL-II Guard Column (4.6 mm I.D. x 10 mm) End-Fitting: Waters type
37997-01 1 pkg 214.00 Buy
COSMOSIL 5SL-II Guard Column (10.0 mm I.D. x 20 mm) End-Fitting: Waters type
37998-91 1 pkg 370.00 Buy
COSMOSIL 5SL-II Guard Column (20.0 mm I.D. x 20 mm) End-Fitting: Waters type
05874-91 1 pkg 808.00 Buy
COSMOSIL 5SL-II Guard Column (20.0 mm I.D. x 50 mm) End-Fitting: Waters type
05875-81 1 pkg 1,087.00 Buy
COSMOSIL 5SL-II Guard Column (28.0 mm I.D. x 50 mm) End-Fitting: Waters type
34359-51 1 pkg 1,910.00 Buy
COSMOSIL 15SL-II Guard Column (28.0 mm I.D. x 50 mm) End-Fitting: Waters type
05892-51 1 pkg 1,755.00 Buy
COSMOSIL 15SL-II Guard Column (50.0 mm I.D. x 50 mm) End-Fitting: Waters type
05894-31 1 pkg 4,125.00 Buy