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COSMOSIL CHiRAL Series

Immobilized Polysaccharide Derivative-Based Chiral Columns

  • Immobilized chiral selectors can withstand many different solvents
  • Sharpen peaks with 3 μm particles
  • Preparative separations with 5 μm particles
  • Equivalent performance to columns currently on the market
  • Competitive price

Conceptual Model

COSMOSIL CHiRAL Series

Immobilized Stationary Phase

High Resistance to Solvents 

The COSMOSIL CHiRAL series uses a chiral selector that is chemically bonded to the silica gel, which results in high resistance to solvents. Tetrahydrofuran (THF) strips coated selectors from the stationary phase, reducing theoretical plates to less than 1/5 in our experiment. However, the same selectors bonded to the silica withstood repeated injections of THF.

Usable Solvents

Due to its immobilized selectors, various solvents are usable with COSMOSIL CHiRAL. A wide variety of solvents increases your selectivity options.

Available in 3 μm Particles

Sharp Peaks

COSMOSIL CHiRAL columns are available in 3 μm particles, which yield sharper peaks than conventional 5 μm particles. Columns for preparative separations are available with 5 μm particles.

Moderate Backpressure

The COSMOSIL CHiRAL 3 series (3 μm particles) puts moderately higher pressure on the system compared to conventional 5 μm particles. This improves reproducibility for low-pressure solvents, such as hexane, that may otherwise cause pump irregularities. As shown in the figure below, increased 2-propanol concentration causes higher pressure. However, even at 50% (v/v), the pressure did not exceed 12 MPa. At the lowest concentration of 5% (v/v), the backpressure was 5.3 MPa. This range allows high flexibility in mobile phase composition and selectivity.

Equivalent Separation to Competitors’ Columns

The COSMOSIL CHiRAL 5 series (5 μm particles) is equivalent to other companies’ immobilized polysaccharide derivative-based chiral columns. 

Same Selectivity with Identical Chiral Selectors

The same chiral selector will yield similar separation patterns. In general, Enantiomers that can be separated on a coated selector can also be separated on an immobilized selector, and those that cannot be separated on one will not be separated on the other. 

Column Selection

COSMOSIL CHiRAL offers 3 different chiral selectors that, together, have a high probability of separating your sample. Of 28 samples in our test, 27 pairs of enantiomers were fully separated. For samples that do not separate easily with any column, please adjust the type and concentration of solvents in your mobile phase. 

Application Data: delta-9-Tetrahydrocannabinol (Δ9 THC) and Cannabichromenic Acid (CBCA) Enantiomers

One of our customers has succeeded in separating Δ-9-THC and CBCA enantiomers using our CHiRAL 5A column.

Cannabinoids of various types have recently become compounds of interest with the potential to treat various ailments. As many of these compounds have optical isomers, separation these enantiomers could prove to be important to research into their therapeutic potential.

 delta-9-Tetrahydrocannabinol (Δ9 THC) Enantiome
Cannabichromenic Acid (CBCA) Enantiomers 

Application Data

COSMOSIL Application Data

COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size

Ordering Information

Product Cat.No. End-Fitting PKG Size Price(US$)  
COSMOSIL CHiRAL 3A Packed Column (3.0 mmI.D. x 100 mm) 21561-81 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 3A Packed Column (4.6 mmI.D. x 150 mm) 15778-51 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 3A Packed Column (4.6 mmI.D. x 250 mm) 15779-41 Waters type 1 pkg 1,873.00 Buy
COSMOSIL CHiRAL 5A Packed Column (4.6 mmI.D. x 250 mm) 15780-01 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 5A Packed Column (10.0 mm I.D. x 250 mm) 15781-91 Waters type 1 pkg 5,725.00 Buy
COSMOSIL CHiRAL 5A Packed Column (20.0 mm I.D. x 250 mm) 15782-81 Waters type 1 pkg 11,396.00 Buy
COSMOSIL CHiRAL 3B Packed Column (3.0 mmI.D. x 100 mm) 21562-71 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 3B Packed Column (4.6 mmI.D. x 150 mm) 15783-71 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 3B Packed Column (4.6 mmI.D. x 250 mm) 15784-61 Waters type 1 pkg 1,873.00 Buy
COSMOSIL CHiRAL 5B Packed Column (4.6 mmI.D. x 250 mm) 15785-51 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 5B Packed Column (10.0 mm I.D. x 250 mm) 15786-41 Waters type 1 pkg 5,725.00 Buy
COSMOSIL CHiRAL 5B Packed Column (20.0 mm I.D. x 250 mm) 15787-31 Waters type 1 pkg 11,396.00 Buy
COSMOSIL CHiRAL 3C Packed Column (3.0 mmI.D. x 100 mm) 21563-61 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 3C Packed Column (4.6 mmI.D. x 150 mm) 15788-21 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 3C Packed Column (4.6 mmI.D. x 250 mm) 15789-11 Waters type 1 pkg 1,873.00 Buy
COSMOSIL CHiRAL 5C Packed Column (4.6 mmI.D. x 250 mm) 15790-71 Waters type 1 pkg 1,712.00 Buy
COSMOSIL CHiRAL 5C Packed Column (10.0 mm I.D. x 250 mm) 15791-61 Waters type 1 pkg 5,725.00 Buy
COSMOSIL CHiRAL 5C Packed Column (20.0 mm I.D. x 250 mm) 15792-51 Waters type 1 pkg 11,396.00 Buy