Immobilized Polysaccharide Derivative-Based Chiral Columns
High Resistance to Solvents
The COSMOSIL CHiRAL series uses a chiral selector that is chemically bonded to the silica gel, which results in high resistance to solvents. Tetrahydrofuran (THF) strips coated selectors from the stationary phase, reducing theoretical plates to less than 1/5 in our experiment. However, the same selectors bonded to the silica withstood repeated injections of THF.
Due to its immobilized selectors, various solvents are usable with COSMOSIL CHiRAL. A wide variety of solvents increases your selectivity options.
COSMOSIL CHiRAL columns are available in 3 μm particles, which yield sharper peaks than conventional 5 μm particles. Columns for preparative separations are available with 5 μm particles.
The COSMOSIL CHiRAL 3 series (3 μm particles) puts moderately higher pressure on the system compared to conventional 5 μm particles. This improves reproducibility for low-pressure solvents, such as hexane, that may otherwise cause pump irregularities. As shown in the figure below, increased 2-propanol concentration causes higher pressure. However, even at 50% (v/v), the pressure did not exceed 12 MPa. At the lowest concentration of 5% (v/v), the backpressure was 5.3 MPa. This range allows high flexibility in mobile phase composition and selectivity.
The COSMOSIL CHiRAL 5 series (5 μm particles) is equivalent to other companies’ immobilized polysaccharide derivative-based chiral columns.
The same chiral selector will yield similar separation patterns. In general, Enantiomers that can be separated on a coated selector can also be separated on an immobilized selector, and those that cannot be separated on one will not be separated on the other.
COSMOSIL CHiRAL offers 3 different chiral selectors that, together, have a high probability of separating your sample. Of 28 samples in our test, 27 pairs of enantiomers were fully separated. For samples that do not separate easily with any column, please adjust the type and concentration of solvents in your mobile phase.
COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size
|COSMOSIL CHiRAL 3A Packed Column (4.6 mmI.D. x 150 mm)||15778-51||Waters type||1 pkg||1,600.00||Buy|
|COSMOSIL CHiRAL 3A Packed Column (4.6 mmI.D. x 250 mm)||15779-41||Waters type||1 pkg||1,750.00||Buy|
|COSMOSIL CHiRAL 5A Packed Column (4.6 mmI.D. x 250 mm)||15780-01||Waters type||1 pkg||1,600.00||Buy|
|COSMOSIL CHiRAL 5A Packed Column (10.0 mm I.D. x 250 mm)||15781-91||Waters type||1 pkg||5,350.00||Buy|
|COSMOSIL CHiRAL 5A Packed Column (20.0 mm I.D. x 250 mm)||15782-81||Waters type||1 pkg||10,650.00||Buy|
|COSMOSIL CHiRAL 3B Packed Column (4.6 mmI.D. x 150 mm)||15783-71||Waters type||1 pkg||1,600.00||Buy|
|COSMOSIL CHiRAL 3B Packed Column (4.6 mmI.D. x 250 mm)||15784-61||Waters type||1 pkg||1,750.00||Buy|
|COSMOSIL CHiRAL 5B Packed Column (4.6 mmI.D. x 250 mm)||15785-51||Waters type||1 pkg||1,600.00||Buy|
|COSMOSIL CHiRAL 5B Packed Column (10.0 mm I.D. x 250 mm)||15786-41||Waters type||1 pkg||5,350.00||Buy|
|COSMOSIL CHiRAL 5B Packed Column (20.0 mm I.D. x 250 mm)||15787-31||Waters type||1 pkg||10,650.00||Buy|
|COSMOSIL CHiRAL 3C Packed Column (4.6 mmI.D. x 150 mm)||15788-21||Waters type||1 pkg||1,600.00||Buy|
|COSMOSIL CHiRAL 3C Packed Column (4.6 mmI.D. x 250 mm)||15789-11||Waters type||1 pkg||1,750.00||Buy|
|COSMOSIL CHiRAL 5C Packed Column (4.6 mmI.D. x 250 mm)||15790-71||Waters type||1 pkg||1,600.00||Buy|
|COSMOSIL CHiRAL 5C Packed Column (10.0 mm I.D. x 250 mm)||15791-61||Waters type||1 pkg||5,350.00||Buy|
|COSMOSIL CHiRAL 5C Packed Column (20.0 mm I.D. x 250 mm)||15792-51||Waters type||1 pkg||10,650.00||Buy|