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Labeling Reagent for LC-MS

L-FDVDA (1-Fluoro-2,4-dinitrophenyl-5-L-valine-N,N-dimethylethylenediamine-amide)

This product is a red to red-yellow crystal or powder that dissolves in acetone. It is a labeling reagent for amino groups and includes a chiral carbon, enabling the separation of labeled amino acids with a C18 or other achiral column (Figure. 1). As the reagent itself is more easily ionizable compared to conventional products, higher sensitivity with LC-MS can be achieved (Figure. 2), and it is suitable for analyzing trace amounts of peptides.

Figure. 1: Chiral separations of L-FDVDA-labeled amino acids

Figure. 1: Chiral separations of L-FDVDA-labeled amino acids

Figure 2. Comparison of detection sensitivity using LC-MS

Figure. 2: Comparison of detection sensitivity using LC-MS

Data provided by Dr. Takefumi Kuranaga, Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University

Ordering Information

Product Cat.No. Formula = M.W. Purity Storage PKG Size Price(US$)  
L-FDVDA (1-Fluoro-2,4-dinitrophenyl-5-L-valine-N,N-dimethylethylenediamine-amide) 20363-24 C15H22N5O5F = 371.36 98.0% or more (HPLC) 4℃ 50 mg 230.00 Buy

The labeling reagent ispatented by Kyoto University. Nacalai Tesque, Inc. produces and distributes this product
under license.