"Quantitative analysis of D/L-serine and D/L-proline in serum by isotope-coded derivatization using an original chiral resolution labeling reagent" was published. 

 

Research Summary:
D-Serine (D-Ser) is a significant co-agonist of the NMDA receptor, crucial for excitatory neurotransmission and linked to neuropsychiatric disorders like Alzheimer's disease (AD), schizophrenia, and depression. A study developed a quantitative method for measuring D/L-serine and D/L-proline in serum using isotope-coded derivatization and liquid chromatography-mass spectrometry, achieving high precision and recovery rates. Results showed significantly elevated %D values of serine and proline in AD patients compared to healthy subjects, indicating the potential of this method for biomarker studies in neuropsychiatric disorders.

 

Journal information:
Journal of Pharmaceutical and Biomedical Analysis Open, Volume 7, June 2026, 100099.
DOI: 10.1016/j.jpbao.2025.100099

 

Products Used in This Study:
DL-Amino Acid Labeling Kit 19942-74 100TESTS 
COSMOCORE® 2.6C18 Packed Column 2.1mmI.D.x100mm 12614-71 1PKG