COSMOCORE 2.6C18
Core-Shell Particle / COSMOCORE UHPLC Columns
Features
- Ultra-high performance LC results with conventional HPLC equipment
- Same number of theoretical plates as sub-2 µm columns with half the back pressure
- Increased loading capacity
- Excellent pH stability (1.5-10)
| COSMOCORE 2.6C18 | |
|---|---|
| Silica gel | Core-shell type silica gel |
| Average particle size | 2.6 µm |
| Core average diameter | 1.6 µm |
| Average pore size | approx. 90Å |
| Specific surface area | approx. 150 m2/g |
| Stationary phase | Octadecyl group |
| Bonding type | Polymeric |
| Main interaction | Hydrophobic interaction |
| Endcapping treatment | Near-perfect treatment |
| Carbon content | approx. 7% |
| Usable pH range | 1.5 - 10 |
| Maximum pressure | 60 MPa |
>> Click here to COSMOCORE Development Kit
Excelent pH Stability
Under accelerated pH 10.4, 40°C stability test, COSMOCORE C18 column shows superior stability compared with other core shell C18 phases.
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Column size:
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2.1 mmI.D. x 100 mm
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Mobile phase:
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0.35% Ammonium hydroxide : Acetonitrile = 90 : 10 (pH 10.4)
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Flow rate:
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0.4 ml/min
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Temperature:
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40°C
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Sample:
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Caffeine (0.05 mg/ml)
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Inj. Vol.:
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1.0 µl
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Same Performance and Lower Back Pressure Compared to Sub-2 mm Particles
COSMOCORE 2.6C18 maintains the same performance as sub-2 µm particles with half the back pressure.
| Column: | COSMOCORE 2.6C18 ... Core shell (2.6 µm) Company A ... Fully porous (1.7 µm, C18) |
| Column size: | 2.1 mmI.D. x 100 mm |
| Mobile phase: | Acetonitrile : Water = 60 : 40 |
| Temperature: | 40°C |
| Detection: | UV 254 nm |
| Sample: | 1. Benzene, 2. Toluene, 3. Ethylbenzene, 4. Propylbenzene, 5. Butylbenzene, 6. Amylbenzene (conc. 2.0 mg/ml) |
| Injection vol.: | 0.5 µl |
Reduced Back Pressure and Faster Analyses
COSMOCORE 2.6C18 delivers performance equivalent to sub-2 µm particles at faster flow rate and analysis time while maintaining a lower back pressure. COSMOCORE can also be used in longer column size to gain additional resolution.
| Column size: | 2.1 mmI.D. x 50 mm |
| Mobile phase: | Acetonitrile : Water = 70 : 30 |
| Temperature: | 40°C |
| Sample: | Amylbenzene |
Higher Retention and Loading Capacity than Competitors' Core-Shell Columns
- Retention
COSMOCORE 2.6C18 features high retention and better separation compared to other core-shell columns
| Column size: | 2.1 mmI.D. x 50 mm |
| Mobile phase: | A: Acetonitrile : Water = 50 : 50 B: Acetonitrile : Water = 80 : 20 B conc. 0 → 100% (0-4 min.), 100% (4-5 min.) |
| Flow rate: | 0.4 ml/min |
| Temperature: | 40°C |
| Detection: | UV 254 nm |
| Sample: | 1. Benzene, 2. Toluene, 3. Ethylbenzene, 4. Propylbenzene 5. Butylbenzene, 6. Amylbenzene, (conc. 2.0 mg/ml) |
| Injection vol.: | 5 µl |
- Higher Loading Capacity
In general, core-shell particles have less surface area and less bonded phase than fully porous particles. COSMOCORE 2.6C18, however, with a large amount of bonded phase, exhibits both high retention and high loading capacity. When injecting 5-10 times more sample volumes in the trace component analysis, COSMOCORE minimizes peak splitting due to the sample over loading.
| Column size: | 2.1 mmI.D. x 50 mm |
| Mobile phase: | A: Acetonitrile : Water = 50 : 50 B: Acetonitrile : Water = 80 : 20 B conc. 0 → 100% (0-4 min.), 100% (4-5 min.) |
| Flow rate: | 0.4 ml/min |
| Temperature: | 40°C |
| Detection: | UV 254 nm |
| Sample: | 1. Benzene, 2. Toluene, 3. Ethylbenzene, 4. Propylbenzene 5. Butylbenzene, 6. Amylbenzene, (conc. 2.0 mg/ml) |
| Injection vol.: | 5 µl |
Low bleed - Suitable for LC-MS
COSMOCORE 2.6C18 has low column bleed, and consequently low MS noise level.
| Column size: | 2.1 mmI.D. x 50 mm |
| Mobile phase: | A: 0.1% Formic Acid B: Acetonitrile B conc. 5 → 100% (0-5 min.), 100% (5-10 min.), 100 → 5% (10-11 min.), 5% (11-17 min.) |
| Flow rate: | 0.2 ml/min |
| Temperature: | 40°C |
| Detection: | MS (TIC (+), MW 50-1000) |
Durability test
COSMOCORE 2.6C18 exhibits high durability. There is no significant deterioration in retention or peak shape after 1,000 injection of amitriptyline.
| Column size: | 2.1 mmI.D. x 50 mm |
| Mobile phase: | A: 0.1% TFA : Water B: 0.1% TFA : Acetonitrile B conc. 5 → 90% (0-3 min.), 90 → 5% (3-3.01 min.), 5% (3.01 - 6 min.) |
| Flow rate: | 0.4 ml/min |
| Temperature: | 40°C |
| Detection: | UV 236 nm |
| Sample: | Amitriptyline (0.2 mg/ml) |
| Injection vol.: | 1.0 µl |
Differences between lots / Sharp Peaks with Many Types of Compounds
COSMOCORE 2.6C18 features a special endcapping treatment that effectively shields residual silanol groups, yielding sharp peaks for basic compounds and metal coordination complexes.
COSMOSIL Application
Ordering Information
Column
| Product | Cat.No. | PKG Size | Price(US$) | |
|---|---|---|---|---|
| COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 30mm | 12632-31 | 1 pkg | 625.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 50mm | 12631-41 | 1 pkg | 670.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 75mm | 12630-51 | 1 pkg | 740.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 100mm | 12614-71 | 1 pkg | 760.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 2.1mmI.D. x 150mm | 12612-91 | 1 pkg | 805.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 30mm | 12611-01 | 1 pkg | 625.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 50mm | 12609-51 | 1 pkg | 670.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 75mm | 12608-61 | 1 pkg | 740.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 100mm | 12607-71 | 1 pkg | 760.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 3.0mmI.D. x 150mm | 12602-21 | 1 pkg | 805.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 30mm | 12601-31 | 1 pkg | 625.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 50mm | 12600-41 | 1 pkg | 670.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 75mm | 12599-91 | 1 pkg | 740.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 100mm | 12598-01 | 1 pkg | 760.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 150mm | 12597-11 | 1 pkg | 815.00 | Buy |
| COSMOCORE 2.6C18 Packed Column, 4.6mmI.D. x 250mm | 12596-21 | 1 pkg | 925.00 | Buy |
Prefilter
| Product | Cat.No. | PKG Size | Price(US$) | |
|---|---|---|---|---|
| U-Fil UHPLC-compatible prefilter | 12571-31 | 1 pkg | 160.00 | Buy |