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SB431542

Cat. No.
: NU03031
Synonyms
: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
CAS No.
: 301836-41-9
Formula
: C22H16N4O3 (384.4)
Appearance
: Yellow powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (30 mg/ml); or ethanol (3 mg/ml)
Storage
: Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
Pharmacology
:  Potent and selective ALK4, ALK5 and ALK7 inhibitor (TGFβ superfamily Type I activin receptor-like kinase). (ALK5 IC50 = 94 nM)1,2. Inhibits TGFβ -induced proliferation of human osteosarcoma cells3. Enhances growth and integrity of embryonic
stem cell-derived endothelial cells4. A frequently used agent employed in numerous stem cell differentiation protocols5. Cell permeable.
References
: 1. NJ Laping et al. Mol. Pharmacol. 2002 62:58
  2. GJ Inman et al. Mol. Pharmacol. 2002 62:65
  3. S Matsuyama et al. Cancer Res. 2003 63:7791
  4. T Watabe et al. J. Cell Biol. 2003 163:1303
  5. N Stanslowsky et al. Stem Cell Res. Ther. 2014 5:35

 

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