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Thiazovivin

Cat. No.
: NU03037 
Synonyms
: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide
CAS No.
: 1226056-71-8
Formula
: C15H13N5OS (311.4)
Appearance
: Off-white powder
Purity
: 98% or more (HPLC), NMR (Conforms)
Solubilization
: May be dissolved in DMSO (30 mg/ml)
Storage
: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.
Pharmacology
: A ROCK inhibitor1. Dramatically improves (200-fold) the efficiency of induced pluripotent stem cell generation from human fibroblasts2. Induces direct conversion of porcine embryonic fibroblasts into adipocytes3. Improves survival of single hESCs on matrigel-coated plates after enzymatic dissociation (more than 30-fold)4. Cell permeable.
References
: 1. E Kajabadi et al. Res. Pharm. Sci. 2012 7:S685
  2. T Lin et al. Nature Methods 2009 6:805
  3. J Zhu et al. Cell Reprogram. 2012 14:99
  4. Y Xu et al. Proc. Natl. Acad. Sci. USA 2010 107:8129

 

 

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