Y-27632
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Cat. No.
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: NU03025
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Synonyms
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: (R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl)cyclohexanecarboxamide, dihydrochloride
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CAS No.
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: 129830-38-2
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Formula
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: C14H21N3O • 2HCl (320.3)
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Appearance
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: White powder
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Purity
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: 98% or more (HPLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (>100 mg/ml), or water (>75 mg/ml)
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Storage
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: Store desiccated as supplied at -20°C for up to 3 years. Store solutions at -20°C for up to 3 months.
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Pharmacology
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: Specific inhibitor of ROCK family kinases1. Enhances stem cell survival and proliferation in culture2. Significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers or differentiation potential3.
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References
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: 1. T Ishizaki et al. Mol. Pharmacol. 2000 57:976 2. K Gauthaman et al. Stem Cell Rev. 2010 6:86 3. X Li et al. Stem Cells Dev. 2008 17:1079 |
