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Y-27632

Cat. No.
: NU03025
Synonyms
: (R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl)cyclohexanecarboxamide, dihydrochloride
CAS No.
: 129830-38-2
Formula
: C14H21N3O • 2HCl (320.3)
Appearance
: White powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (>100 mg/ml), or water (>75 mg/ml)
Storage
: Store desiccated as supplied at -20°C for up to 3 years. Store solutions at -20°C for up to 3 months.
Pharmacology
:  Specific inhibitor of ROCK family kinases1. Enhances stem cell survival and proliferation in culture2. Significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers or differentiation potential3.
References
: 1. T Ishizaki et al. Mol. Pharmacol. 2000 57:976
  2. K Gauthaman et al. Stem Cell Rev. 2010 6:86
  3. X Li et al. Stem Cells Dev. 2008 17:1079

 

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