COSMOSIL C18-MS-II
Reversed Phase / Monomeric C18
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COSMOSIL 5C18-MS-II is a monomeric type of C18 phase. A new endcapping treatment with polar groups for "shield effect" has extended the pH range and significantly improved peak shape for basic compounds. This phase is recommended for most of applications but particularly effective for low molecular weight organic compounds.
| COSMOSIL C18-MS-II | ||
|---|---|---|
| USP code | L1 | |
| Silica gel | High purity porous spherical silica | |
| Average particle size | 2.5 µm | 3 µm, 5 µm, 15 µm |
| Average pore size | approx. 130Å | approx. 120Å |
| Specific surface area | approx. 330m2/g | approx. 300m2/g |
| Stationary phase | Octadecyl group | Octadecyl group |
| Bonding Type | Monomeric type | Monomeric type |
| End capping treatment | Near-perfect treatment | Near-perfect treatment |
| Carbon content | approx. 18% | approx. 16% |
| pH range | 2 - 10 | 2 - 10 |
Separation Property
The COSMOSIL 5C18-MS-II is a well-balanced column with better basic performance, such as sharper peaks for basic compounds and chelating compounds, strong hydrophobic interaction, low analytical pressure, and high theoretical plate number. COSMOSIL 5C18-MS-II is the first-choice column for reversed-phase chromatography.
Stability under alkaline condition
Column: COSMOSIL 5C18-MS-II 4.6 x 150 mm
Application for nitrosamine analysis
Application for nitrosamine analysis
Nitrosamines are a group of compounds that result from various pharmaceutical synthesis processes, especially amine reactions. They are potential carcinogens and genotoxins, and their unexpected presence in drugs has been the cause of some recalls and resulting drug shortages.
We have developed a chromatographic method which separates 8 nitrosamines on our 5C18-MS-2 column. This enables detection and quantification of these compounds of concern.
Analysis of Basic Compounds and Metal Coordination Compounds
The COSMOSIL 5C18-MS-II column, taking advantage of a new end-capping treatment, can replace the original COSMOSIL C18 (ODS) column. A new end-capping treatment with polar groups for "shield effect" has significantly improved peak shape for basic compounds. Ultra pure silica gel with low trace-metal content is used for COSMOSIL columns; thus the columns provide excellent peak shapes for chelating compounds.
Fast LC Columns（COSMOSIL 2.5C18-MS-II）
* This application was taken using a semi-micro HPLC instrument, setting the detector response time to 0.02 sec.
COSMOSIL Application Search
COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size
Ordering Information
2.5 μm particle size
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 2.5C18-MS-II Packed Column (1.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 12647-51 | 1 pkg | 806.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (1.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 07594-01 | 1 pkg | 806.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (1.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 07603-71 | 1 pkg | 806.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (2.0 mm I.D. x 30 mm) | End-Fitting: Waters type | 11379-01 | 1 pkg | 671.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (2.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 08994-31 | 1 pkg | 671.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (2.0 mm I.D. x 75 mm) | End-Fitting: Waters type | 08995-21 | 1 pkg | 671.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (2.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 08996-11 | 1 pkg | 671.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (3.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 08997-01 | 1 pkg | 671.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (3.0 mm I.D. x 75 mm) | End-Fitting: Waters type | 08998-91 | 1 pkg | 671.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (3.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 08999-81 | 1 pkg | 671.00 | Buy |
3 μm particle size
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 50 mm) | End-Fitting: Waters type | 05514-01 | 1 pkg | 570.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 75 mm) | End-Fitting: Waters type | 34470-71 | 1 pkg | 530.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 100 mm) | End-Fitting: Waters type | 34367-41 | 1 pkg | 565.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 150 mm) | End-Fitting: Waters type | 08723-71 | 1 pkg | 624.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 250 mm) | End-Fitting: Waters type | 09995-91 | 1 pkg | 765.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (3.0 mm l.D. x 100 mm) | End-Fitting: Waters type | 34366-51 | 1 pkg | 495.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (3.0 mm l.D. x 150 mm) | End-Fitting: Waters type | 07267-91 | 1 pkg | 530.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 10 mm) | End-Fitting: Waters type | 38065-71 | 1 pkg | 394.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 50 mm) | End-Fitting: Waters type | 38066-61 | 1 pkg | 394.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 75 mm) | End-Fitting: Waters type | 08758-31 | 1 pkg | 570.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 100 mm) | End-Fitting: Waters type | 38067-51 | 1 pkg | 570.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 150 mm) | End-Fitting: Waters type | 04785-91 | 1 pkg | 624.00 | Buy |
5 μm, 15 μm particle size
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Packed Column (1.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 02824-31 | 1 pkg | 530.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (1.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 02896-01 | 1 pkg | 570.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 30 mm) | End-Fitting: Waters type | 05876-71 | 1 pkg | 530.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 04355-21 | 1 pkg | 530.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 05597-31 | 1 pkg | 595.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 38025-91 | 1 pkg | 595.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 05761-61 | 1 pkg | 653.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (3.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 05458-51 | 1 pkg | 595.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (3.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 34245-31 | 1 pkg | 595.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (3.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 34254-11 | 1 pkg | 653.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 30 mm) | End-Fitting: Waters type | 34341-61 | 1 pkg | 424.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 50 mm) | End-Fitting: Waters type | 38017-01 | 1 pkg | 424.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 100 mm) | End-Fitting: Waters type | 38018-91 | 1 pkg | 518.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 150 mm) | End-Fitting: Waters type | 38019-81 | 1 pkg | 518.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 150 mm) (3 Lots Set) | End-Fitting: Waters type | 09397-73 | 3 pkg | 1,548.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 250 mm) | End-Fitting: Waters type | 38020-41 | 1 pkg | 559.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (6.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 38021-31 | 1 pkg | 730.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (6.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 38022-21 | 1 pkg | 800.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (10.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 05789-21 | 1 pkg | 782.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (10.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 09479-61 | 1 pkg | 941.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (10.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 34355-91 | 1 pkg | 1,059.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (10.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 38023-11 | 1 pkg | 1,371.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (20.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 16580-91 | 1 pkg | 2,207.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (20.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 05091-41 | 1 pkg | 2,325.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (20.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 38024-01 | 1 pkg | 2,954.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (28.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 16582-71 | 1 pkg | 5,061.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (28.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 16583-61 | 1 pkg | 5,296.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (28.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 05760-71 | 1 pkg | 6,215.00 | Buy |
| COSMOSIL 15C18-MS-II Packed Column (20.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 08578-91 | 1 pkg | 2,118.00 | Buy |
| COSMOSIL 15C18-MS-II Packed Column (20.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 22598-91 | 1 pkg | 2,695.00 | Buy |
| COSMOSIL 15C18-MS-II Packed Column (28.0 mm l.D. x 250 mm) | End-Fitting: Waters type | 34525-61 | 1 pkg | 5,261.00 | Buy |
| COSMOSIL 15C18-MS-II Packed Column (50.0 mm l.D. x 250 mm) | End-Fitting: Waters type | 05886-41 | 1 pkg | 8,731.00 | Buy |
| COSMOSIL 15C18-MS-II Packed Column (50.0 mm l.D. x 500 mm) | End-Fitting: Waters type | 34531-71 | 1 pkg | 16,544.00 | Buy |
Guard Column / Guard Cartridge
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 3C18-MS-II Guard Cartridge (4.6 mm I.D. x 10 mm) | End-Fitting: Waters type | 21234-84 | 2 pkg | 206.00 | Buy |
| COSMOSIL 5C18-MS-II Guard Column (2.0 mm I.D. x 10 mm) | End-Fitting: Waters type | 06097-51 | 1 pkg | - | Inquire |
| COSMOSIL 5C18-MS-II Guard Cartridge (4.6 mm I.D. x 10 mm) | End-Fitting: Waters type | 38015-89 | 3 pkg | 206.00 | Buy |
| COSMOSIL 5C18-MS-II Guard Column (10.0 mm I.D. x 20 mm) | End-Fitting: Waters type | 38016-11 | 1 pkg | 495.00 | Buy |
| COSMOSIL 5C18-MS-II Guard Column (20.0 mm I.D. x 20 mm) | End-Fitting: Waters type | 05790-81 | 1 pkg | 1,089.00 | Buy |
| COSMOSIL 5C18-MS-II Guard Column (20.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 34371-71 | 1 pkg | 1,654.00 | Buy |
| COSMOSIL 5C18-MS-II Guard Column (28.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 34347-01 | 1 pkg | 3,084.00 | Buy |
| COSMOSIL 15C18-MS-II Guard Column (20.0 mm l.D. x 50 mm) | End-Fitting: Waters type | 34524-71 | 1 pkg | 1,177.00 | Buy |
| COSMOSIL 15C18-MS-II Guard Column (28.0 mm l.D. x 50 mm) | End-Fitting: Waters type | 05885-51 | 1 pkg | 2,583.00 | Buy |
| COSMOSIL 15C18-MS-II Guard Column (50.0 mm l.D. x 50 mm) | End-Fitting: Waters type | 34527-41 | 1 pkg | 4,449.00 | Buy |
HPLC Accessories
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL Guard Cartridge Holder (2.0 mm I.D.) | End-Fitting: Waters type | 11884-71 | 1 pkg | 291.00 | Buy |
| COSMOSIL Direct Cartridge Holder | End-Fitting: Waters type | 19989-71 | 1 pkg | 297.00 | Buy |
| COSMOSIL Guard Cartridge Holder (4.6 mm I.D.) **Discontinued** | End-Fitting: Waters type | 38009-79 | 1 pkg | - | Inquire |
| COSMOSIL Column Spare Filter for Prefilter (1 micron) | End-Fitting: Waters type | 39539-09 | 2 pkg | 60.00 | Buy |
| COSMOSIL Column Connecting Tube (0.25 mm) | End-Fitting: Waters type | 37843-69 | 1 pkg | 71.00 | Buy |
| COSMOSIL Column Connecting Tube (0.1 mm) | End-Fitting: Waters type | 12570-41 | 1 pkg | 71.00 | Buy |
| COSMOSIL Column Prefilter | End-Fitting: Waters type | 39361-19 | 1 pkg | 159.00 | Buy |
** Guard cartridges require a guard cartridge holder.
** #38009-79 has been discontinued. Alternative product is COSMOSIL Direct Cartridge Holder (#19989-71).