B-cell lymphoma 2
|BCL2 is a member of B cell lymphoma 2 (BCL2) family, which are key regulators in intrinsic apoptosis. BCL2 consists of a hydrophobic pocket to which BH3 helixes bind, preventing apoptosis and cell death. Overexpression of BCL2 has been reported in many cancers and the inhibition of BCL2 activity is a promising approach for cancer therapy.|
|Synonym(s):||B-cell lymphoma 2|
|Molecular Weight :||24.7 kDa|
|Tag :||C-terminal His Tag|
|Source :||Escherichia Coli.|
Greater than 95%, as determined by SDS-PAGE
|Concentration :||0.6 mg/ml|
|Formulation :||25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 2 mM DTT, 10% Glycerol|
|GeneBank Accession # :||P10415, a.a. 1-211|
|Application :||Inhibitor Screening, binding assays|
|Storage :||Stable for 12 months at -80°C, Avoid freeze/thaw cycles|
Vogler, M., Adv Med. 2014. 2014:943648.
Hata, A., et al., Cancer Discov. 2015 May;5(5):475-87.
|Recombinant Human BCL2||NU03051||95 % or more (SDS-PAGE)||-80°C||100 µg||399.00||Buy|