Animal component-free, Endotoxin-free, Biorisk-free / Next-generation Growth Factors for Stem Cells and Cell-based applications
Insulin-like growth factors (IGFs) are similar to insulin by structure and function, but have a much higher growth-promoting activity. They are required for embryonic development, and are produced mainly in the liver in response to a hepatocyte growth hormone. It can be used to substitute insulin for the maintenance of human pluripotent stem cells. IGF-1 LR3 is a recombinant synthetic growth factor of ~9.1 kDa, single polypeptide chain containing 83 amino acid residues. It is an analog of IGF-1 comprised of the complete IGF-1 sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension. It has been engineered for higher biological potency in vitro, with an increased half-life.
This recombinant IGF-1 LR3 product is a highly potent growth factor ideal for stem cell research and cell manufacturing applications, including cells of the ectoderm linage (oligodendrocytes, motor neurons), and mesoderm linage (osteocytes, chondrocytes and muscle cells).
|50µg, 1000µg. Core Biogenesis is unlocking the powers of the bioeconomy by ensuring the scalability of world changing technologies as regenerative medicine and cellular agriculture. Contact us directly for lot reservation and (large/bulk/industry/production) quantities.
|Engineered protein sequence.
|≥ 95% measured by SDS page, and resolved under reduced (R) conditions.
|The biological activity of recombinant IGF-1 LR3 protein was determined by its ability to promote the proliferation of cells cultured in adherent condition. Cell proliferation is measured using non-radioactive colorimetric assay and monitored by absorbance. EC50 is generally: ≤ 0.5 ng/mL
|Recombinant protein expressed in plant system, free of bacterial endotoxins.
|Animal-derived Component Free. Core Biogenesis strictly guarantees that our recombinant proteins are not produced with or contain any components of animal origin.