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About Core Shell Particles

Core-shell particles consist of a nonporous core inside a porous shell. By using these core-shell particles, one can achieve sharper peaks compared to fully porous silica gel particles of the same diameter.









For more information, please visit the link below;  


• COSMOCORE 2.6Cholester


• COSMOCORE Method Development Kit


Uniform Particle Size Distribution Compared to 1.7 µm Particles

Compared to fully porous particles, core-shell particles have a more uniform particle diameter therefore, core-shell particles can be packed in the column more uniformly to minimize sample diffusion.

COSMOCORE 2.6C18 (200x)                              Fully porous 1.7 µm particles (200x)                



Mass Transfer Equivalent to Fully Porous sub-2 µm Particles

Mass transfer refers to the time it takes for a sample molecule to enter and leave a particle. In general, lower mass transfer time corresponds to less diffusion and sharper peaks. Even though COSMOCORE 2.6C18 has a larger particle diameter than fully porous sub-2 µm particles, the mass transfer characteristics are similar.

         COSMOCORE 2.6C18                                              Fully porous sub-2 µm particle

COSMOCORE UHPLC Columns (Specifications)

USP Code L 1 L 101  
Silica gel Core-Shell type silica
Particle size  2.6 µm
Core average diameter  1.6 µm
Average pore size approx. 90Å
Specific surface area approx. 300 m²/g
Stationary phase

Octadecyl Group

Cholesteryl Group

Pentabromobenzyl group

Main Interaction Hydrophobic interaction 
Hydrophobic interaction
Molecular shape selectivity 
Hydrophobic interaction
Dispersion force 
Endcapping treatment Near-Perfect Treatment
Carbon content  approx. 7% - -
pH range 1.5 - 10.0 2 - 7.5 2 - 7.5
Max. Pressure 60 MPa
For more information, please visit the link below;  


• COSMOCORE 2.6Cholester


• COSMOCORE Method Development Kit




COSMOSIL Application Search

COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size