Nacalai USA - Innovations for Life Sciences

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About Core Shell Particles

Core-shell particles consist of a nonporous core inside a porous shell. By using these core-shell particles, one can achieve sharper peaks compared to fully porous silica gel particles of the same diameter.

Uniform Particle Size Distribution Compared to 1.7 µm Particles

Compared to fully porous particles, core-shell particles have a more uniform particle diameter therefore, core-shell particles can be packed in the column more uniformly to minimize sample diffusion.

COSMOCORE 2.6C18 (200x)                              Fully porous 1.7 µm particles (200x)                

 

 

Mass Transfer Equivalent to Fully Porous sub-2 µm Particles

Mass transfer refers to the time it takes for a sample molecule to enter and leave a particle. In general, lower mass transfer time corresponds to less diffusion and sharper peaks. Even though COSMOCORE 2.6C18 has a larger particle diameter than fully porous sub-2 µm particles, the mass transfer characteristics are similar.

         COSMOCORE 2.6C18                                              Fully porous sub-2 µm particle

Specifications

Column  COSMOCORE 2.6C18 COSMOCORE 2.6Cholester COSMOCORE 2.6PBr
USP Code   L 101  
Silica Gel Core-shell type silica
Particle Size 2.6 µm
Average Pore Size 1.6 µm 
Pore Size approx. 90 Å
Specific Surface Area approx. 150 m2/g
Stationary Phase

Octadecyl Group

Cholesteryl Group

Pentabromobenzyl Group

Main Interaction Hydrophobic interaction 
Hydrophobic interaction
Molecular shape selectivity 
Hydrophobic interaction
Dispersion force 
End Capping  Near-perfect Treatment
Carbon Content approx. 7 %  - -
pH Range 1.5 - 10  2.0 - 7.5 2.0 - 7.5 
Max. Puressure 60 MPa