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A83-01

Cat. No.
: NU09014
Synonyms
: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
CAS No.
: 909910-43-6
Formula
: C25H19N5S (421.5)
Appearance
: Pale-yellow powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (20 mg/ml)
Storage
: Store desiccated as supplied at -20°C for up to 3 years. Store solutions at -20°C for up to 2 months.
Pharmacology
:  Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.
References
: 1. J Vogt et al. Cell Signal. 2011 23:1831
  2. M Tojo et al. Cancer Sci. 2012 96:791
  3. W Li et al. Cell Stem Cell 2009 4:16
  4. X Yuan et al. Stem Cells 2011 29:549

 

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