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CHIR99021

Cat. No.
: NU03026
Synonyms
: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]-ethyl]amino]-3-pyridinecarbonitrile
  CT-99021
CAS No.
: 252917-06-9
Formula
: C22H18Cl2N8 (465.3)
Appearance
: Beige powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (25 mg/ml, warm)
Storage
: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months
Pharmacology
:  Potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells2. Promotes replication and survival of pancreatic beta cells3. Enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors4. Cell permeable and active in vivo.
References
: 1. CN Bennett et al. J. Biol. Chem. 2002 277:30998
  2. CN Bennett et al. PNAS 2005 102:3324
  3. R Mussmann et al. J. Biol. Chem. 2007 282:12030
  4. AP Manceur et al. Exp. Cell Res. 2011 317:2086

 

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