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DAPT

Cat. No.
: NU03028
Synonyms
: N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
  LY-374973
CAS No.
: 208255-80-5
Formula
: C23H26F2N2O4 (432.5)
Appearance
: White powder
Purity
: 98% or more (TLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (30 mg/ml)
Storage
: Store as supplied at -20°C for up to 1 year. Solutions in DMSO may be stored at -20°C for up to 3 months.
Pharmacology
:  Inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ in brain extract, cerebrospinal fluid and plasma from mice and rats2,3. DAPT blocks Notch signaling which promotes neuronal differentiation of precursor cells4. Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable.
References
: 1. HF Dovey et al. J. Neurochem. 2001 76:173
  2. E Portelius et al. Cell Signal 2009 5:615
  3. M El Mouedden et al. Curr. Pharma. Des. 2006 12:1671
  4. M De Smedt et al. Blood 2005 106:2236
  5. JK Ichida et al. Nature Chem. Biol. 2014 10:632

 

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