Dexamethasone
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Cat. No.
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: NU03027
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Synonyms
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: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
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CAS No.
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: 50-02-2
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Formula
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: C22H29FO5 (392.5)
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Appearance
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: White powder
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Purity
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: 98% or more (TLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (40 mg/ml)
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Storage
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: Store, as supplied, desiccated at ambient temperature. Store solutions at -20°C for up to 3 months.
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Pharmacology
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: A synthetic anti-inflammatory glucocorticoid. Induces apoptosis in a variety of cell types1,2. It inhibits proliferation of A549 human lung adenocarcinoma cells and induces cell surface expression of lipocortin-13. Induces osteogenic differentiation of human mesenchymal stem cells4. Induces indoleamine-2,3-dioxygenase (IDO) and exerts IDO-dependent protection in a model of allergic airway inflammation5.
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References
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: 1. HO Fernhead et al. Biochem. Pharmacol. 1994 48:1073 2. D Chauhan et al. J. Biol. Chem. 2000 275:27845 3. JD Croxtall and RJ Flower Proc. Natl. Acad. Sci. USA 1992 89:3571 4. YC Liu et al. Biosci. Trends 2014 8:138 5. U Grohmann et al. Nat. Med. 2007 13:579 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| Dexamethasone | 50-02-2 | 98% (TLC) | Room Temp. | NU03027 | 100 mg | 80.00 | Buy |