Nacalai USA - Innovations for Life Sciences

Subtotal: $0.00

View Cart

Dexamethasone

Cat. No.
: NU03027
Synonyms
: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS No.
: 50-02-2
Formula
: C22H29FO5 (392.5)
Appearance
: White powder
Purity
: 98% or more (TLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (40 mg/ml)
Storage
: Store, as supplied, desiccated at ambient temperature. Store solutions at -20°C for up to 3 months.
Pharmacology
:  A synthetic anti-inflammatory glucocorticoid. Induces apoptosis in a variety of cell types1,2. It inhibits proliferation of A549 human lung adenocarcinoma cells and induces cell surface expression of lipocortin-13. Induces osteogenic differentiation of human mesenchymal stem cells4. Induces indoleamine-2,3-dioxygenase (IDO) and exerts IDO-dependent protection in a model of allergic airway inflammation5.
References
: 1. HO Fernhead et al. Biochem. Pharmacol. 1994 48:1073
  2. D Chauhan et al. J. Biol. Chem. 2000 275:27845
  3. JD Croxtall and RJ Flower Proc. Natl. Acad. Sci. USA 1992 89:3571
  4. YC Liu et al. Biosci. Trends 2014 8:138
  5. U Grohmann et al. Nat. Med. 2007 13:579

 

>> Click here for ordering information.