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Dorsomorphin

Cat. No.
: NU03030
Synonyms
: 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine
  BML-275
CAS No.
: 866405-64-3
Formula
: C24H25N5O (399.5)
Appearance
: Pale-yellow powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (4 mg/ml, warm)
Storage
: Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Pharmacology
:  A potent, selective and reversible ATP-competitive inhibitor of AMPactivated protein kinase (AMPK), Ki = 109 nM in the presence of ATP and absence of AMP1. Displays no significant inhibition of JAK3, PKA, PKCθ, SYK and ZAPK. Suppresses food
intake in mice2 and inhibits the effects of AICAR and metformin1. It also inhibits BMP type 1 receptors ALK2, ALK3 and ALK63. Promotes cardiomyogenesis in mouse embryonic stem cells4. Induces autophagy in tumor cell lines via an AMPK-independent pathway5. Cell permeable.
References
: 1. G Zhou et al. J. Clin. Invest. 2001 108:1167
  2. EK Kim et al. J. Biol. Chem. 2004 279:19970
  3. PB Yu et al. Nat. Chem. Biol. 2008 4:33
  4. J Hao et al. PloS One 2008 3:e2904
  5. L Vucicevic et al. Autophagy 2011 7:40

 

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