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Forskolin

Cat. No.
: NU03029
Synonyms
: 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
CAS No.
: 66575-29-9
Formula
: C22H34O7 (410.5)
Appearance
: White powder
Purity
: 99% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (10 mg/ml); or ethanol (4 mg/ml). Note, DMSO is the solvent of choice in experimental protocols for adenylate cyclase activation. Do not use ethanol which inhibits forskolin-stimulated adenylate cyclase.
Storage
: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 4 months.
Pharmacology
:  Extremely useful activator of adenylate cyclase (EC50=2-10 µM)1,2. A hypotensive, vasodilatory and positive inotropic agent3. Induces stem cell neuronal differentiation4. Cell permeable and active in vivo.
References
: 1. PA Insel and RS Ostrom Cell Mol. Neurobiol. 2003 23:305
  2. A Laurenza et al. Trends Pharmacol. Sci. 1989 10:442
  3. NJ De Souza Med. Res. Rev. 1983 3:201
  4. SS Kim et al. Neuroreport 2005 16:1357

 

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