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trans-ISRIB

Cat. No.
: NU03040
Synonyms
: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]; trans-ISRIB
CAS No.
: 1597403-47-8
Formula
: C22H24NCl2N2O4 (451.3)
Appearance
: White powder
Purity
: 98% or more (TLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (5 mg/ml, warm)
Storage
: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Pharmacology
:  Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM1. Enhances spatial and fear-associated learning in mice and enhances cognitive function1,2. Mechanism of action involves activation of eiF2β3. Suppresses ER stress-induced inflammatory gene expression4. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production5. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models6.
References
: 1. C Sidrauski et al. Elife 2013 2:e00498
  2. Y Sekine et al. Science 2015 348:1027
  3. C Sidrauski et al. Elife 2015 4:e07314
  4. LN Guthrie et al. J. Biol. Chem. 2016 291:15830
  5. T Hosoi et al. J. Pharmacol. Sci. 2016 131:292
  6. A Chou et al. Proc. Natl. Acad. Sci. USA 2017 114:E6420

 

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