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IWP-2

Cat. No.
: NU03032
Synonyms
: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
CAS No.
: 686770-61-6
Formula
: C22H18N4O2S3 (466.6)
Appearance
: White powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (5 mg/ml; warm)
Storage
: Store desiccated as supplied at -20°C for up to 3 years. Store solutions at -20°C for up to 2 months.
Pharmacology
:  IWP-2 is an inhibitor of Wnt secretion and processing. It blocks Wntdependent signaling (IC50=27 nM) by inhibition of the O-palmitoyltransferase Porcn1. Induces cardiomyocyte differentiation from human pluripotent stem cells2. An important tool for probing the involvement of the Wnt pathway in physiological processes3,4. Cell permeable.
References
: 1. B Chen et al. Nature Chem. Biol. 2009 5:100
  2. X Lian et al. Proc. Natl. Acad. Sci. USA 2012 109:1848
  3. D ten Berge et al. Nature Cell Biol. 2011 13:1070
  4. M Uyama et al. Int. J. Mol. Med. 2013 31:1243

 

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