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IWR-1-endo

Cat. No.
: NU03035
Synonyms
: 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinylbenzamide
CAS No.
: 1127442-82-3
Formula
:  C25H19N3O3 (409.4)
Appearance
: Off-white to yellow powder
Purity
: 98% or more (TLC/HPLC), NMR (Conforms)
Solubilization
: May be dissolved in DMSO (10 mg/ml) 
Storage
: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Pharmacology
: A potent inhibitor of Wnt signaling (IC50=180 nM)1. Inhibits zebrafish tailfin regeneration (0.5 µM)2. Acts via inhibition of tankyrase and attenuates wnt/β-catenin signaling in cancer stem-like cells3. Promotes self-renewal and maintains pluripotency of human embryonic stem cells4. Promotes differentiation of pluripotent stem cells into cardiomyocytes5.
References
: 1. B Chen et al. Nature Chem. Biol. 2009 5:100
  2. J Lu et al. Biorg. Med. Chem. Lett. 2009 19:3825
  3. SR Martins-Neves et al. Cancer Lett. 2018 414:1
  4. H Kim et al. Nature Commun. 2013 4:3403
  5. Y Ren et al. J. Mol. Cell. Cardiol. 2011 51:280

 

 

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