LDN-193189
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Cat. No.
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: NU03038
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Synonyms
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: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, dihydrochloride
LDN-193189 HCl
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CAS No.
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: 1435934-00-1
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Formula
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: C25H22N6 • 2HCl (479.4)
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Appearance
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: Orange powder
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Purity
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: 98% or more (HPLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (5 mg/ml) or water (5 mg/ml)
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Storage
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: Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 2 months.
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Pharmacology
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: LDN-193189 HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation1. Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells2, 3. LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone4.
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References
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: 1. PB Yu et al. Nat. Med. 2008 14:1363 2. SM Chambers et al. Nat. Biotechnol. 2012 30:715 3. FR Kreitzer et al. Am. J. Stem Cells 2013 2:119 4. YC Lee et al. Cancer Res. 2011 71:5194 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | Cat.No. | CAS No. | Purity | Storage | PKG Size | Price(US$) | |
|---|---|---|---|---|---|---|---|
| LDN 193189 | NU03038 | 1435934-00-1 | 98% (HPLC) | Room Temp. | 10 mg | 180.00 | Buy |