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LDN-193189

Cat. No.
: NU03038
Synonyms
: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, dihydrochloride
  LDN-193189 HCl
CAS No.
: 1435934-00-1
Formula
: C25H22N6 • 2HCl (479.4)
Appearance
: Orange powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (5 mg/ml) or water (5 mg/ml)
Storage
: Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 2 months.
Pharmacology
:  LDN-193189 HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation1. Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells2, 3. LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone4.
References
: 1. PB Yu et al. Nat. Med. 2008 14:1363
  2. SM Chambers et al. Nat. Biotechnol. 2012 30:715
  3. FR Kreitzer et al. Am. J. Stem Cells 2013 2:119
  4. YC Lee et al. Cancer Res. 2011 71:5194

 

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