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PD-325901

Cat. No.
: NU03033
Synonyms
: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
CAS No.
: 391210-10-9
Formula
: C16H14F3IN2O4 (482.2)
Appearance
: White powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (12 mg/ml)
Storage
: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Pharmacology
:  A selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM)1. Inhibits growth and/or proliferation of a variety of cancer cells2. Enhances self-renewal of embryonic stem cells3. In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells4. In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells5.
References
: 1. SD Barrett et al. Bioorg. Med. Chem. Lett. 2008 18:6501
  2. L Ciuffreda et al. Neoplasia 2009 11:720
  3. Z Ai et al. Stem Cells Int. 2016 2016:1792573
  4. C Li et al. Oncotarget 2016 7:39730
  5. W Li et al. Cell Stem Cell 2009 4:16

 

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