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RepSox

Cat. No.
: NU03036
Synonyms
: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
  E-616452
  SNJ 2511
CAS No.
: 446859-33-2
Formula
: C17H13N5 (287.3)
Appearance
: Pale-yellow powder
Purity
: 98% or more (HPLC), NMR (Conforms) 
Solubilization
: May be dissolved in DMSO (25 mg/ml); or Ethanol (10 mg/ml)
Storage
: Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 1 month.
Pharmacology
:  RepSox is a potent inhibitor of the TGF-β type I receptor (ALK5), IC50 ALK5 auto-P= 4 nM and IC50 TGF-β cellular assay = 23 nM1. RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog ranscription2,3. It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021)4,5.
References
: 1. F Gellibert et al. J. Med. Chem. 2004 47:4494
  2. JK Ichida et al. Cell Stem Cell 2009 5:491
  3. W Li et al. Cell Stem Cell 2009 4:16   /    L Cheng et al. Cell Res. 2015 25:1269
  4. L Cheng et al. Cell Res. 2014 24:665

 

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