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Rosiglitazone

Cat. No.
: NU03034
Synonyms
: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
  BRL-49653
CAS No.
: 122320-73-4
Formula
: C18H19N3O3S (357.4)
Appearance
: White powder
Purity
: 98% or more (TLC/HPLC), NMR (Conforms)
Solubilization
: May be dissolved in DMSO (50 mg/ml); or DMF (40 mg/ml)
Storage
: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Pharmacology
: Prototypical TZD antidiabetic agent. Potent and selective PPARγ agonist (Kd=43 nM)1,2. Clinically useful antihyperglycemc agent3. Induces a brown fat gene program in subcutaneous white adipose tissue via activation of the PRDM16 protein4.
Induces differentiation of pluripotent stem cells into adipocytes5
References
: 1. BC Cantello et al. J. Med. Chem. 1994 37:3977
  2. JM Lehmann et al. J. Biol. Chem. 1995 270:12953
  3. TM Wilson et al. J. Med. Chem. 1996 39:665
  4. O Haruya et al. Cell Metab. 2012 15:395
  5. DJ Ruiz-Ojeda et al. Int. J. Mol. Sci. 2016 17:1040

 

 

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