This product leads to effective elution of antibodies from protein A columns under mild pH (pH 4.0). Normally, antibodies are not effectively eluted at pH 4.0. Use of a lower pH can lead to partial denaturation and subsequent aggregation of the eluted antibodies. This product is based on the unique characteristics of arginine, which suppresses protein-protein interactions.
This product is manufactured with permission from Ajinomoto Co., Inc. based on the patent US 8084032, 8435527, 2012-0264918*.
*JP: 4826995, US: 8084032, 8435527, 2012-0264918, EP: 1568710, CN: 1680426
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