Nacalai USA - Innovations for Life Sciences

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Arg-Antibody Elution Buffer, pH4.0

This product leads to effective elution of antibodies from protein A columns under mild pH (pH 4.0). Normally, antibodies are not effectively eluted at pH 4.0. Use of a lower pH can lead to partial denaturation and subsequent aggregation of the eluted antibodies. This product is based on the unique characteristics of arginine, which suppresses protein-protein interactions.

This product is manufactured with permission from Ajinomoto Co., Inc. based on the patent US 8084032, 8435527, 2012-0264918*.

*JP: 4826995, US: 8084032, 8435527, 2012-0264918, EP: 1568710, CN: 1680426


  • Enables effective elution of antibodies from protein A column, reducing potential risk of acid denaturation and resultant aggregation
  • Virus inactivation, a key step of clinical antibody manufacturing, is enhanced by arginine
  • The use of this product has no impact on the preceding processes of antibody purification, e.g., loading step of cell culture medium and the following column washing step
  • Flexible customization of Arginine-based elution buffers on demand

Elution from Protein A using L-Arginine



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