Recombinant Human MALT1
| MALT1 is a cysteine protease involved in numerous different signaling pathways, including T cell receptor dependent NF-kB signaling. Its role in NFkB regulation makes it a potential therapeutic target for autoimmune disorders as well as B cell lymphoma. |
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Synonym(s):
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Mucosa-associated lymphoid tissue lymphoma translocation protein 1, paracaspase-1
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Molecular Weight :
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44.1 kDa
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Tag :
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C-terminal 6x-His
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Source :
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E. coli
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Purity :
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Greater than 90%, as determined by SDS-PAGE
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Activity:
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Concentration :
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0.6 mg/ml
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Formulation :
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25 mM HEPES pH7.5; 300 mM NaCl; 5 mM DTT
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GeneBank Accession # :
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NM_006785.4, a.a. 338-719
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Application :
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Inhibitor Screening, Cleavage Assays
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Storage :
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Stable for 12 months at -80°C, Avoid freeze/thaw cycles
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Reference :
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Rebeaud, F., et al., Nat Immunol. 2008;9(3):272-281.
Lucas, P.C., et al., J Biol Chem. 2001;276(22):19012-19019.
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