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Recombinant Human SOS1

Son of Sevenless Homolog 1

SOS1 is a guanine nucleotide exchange factor (GEF) for RAS proteins, which are membrane associated proteins involved in various signaling pathways. RAS proteins are activated by GEF-facilitated GDP exchange for GTP, and inactivated by GTP hydrolysis. RAS signaling is upregulated in many different cancers, thus making RAS activation via SOS1 interaction a promising target for cancer therapy. 

 

Synonym(s): 
Son of Sevenless Homolog 1
Molecular Weight : 
57.4 kDa
Tag : 
N-terminal His-Avi-tagged
Source :
E. coli
Purity :
Greater than 90%, as determined by SDS-PAGE
Concentration :
0.6 mg/ml
Formulation : 
25 mM Tris HCl pH 7.5, 50 mM NaCl, 1 mM DTT
GeneBank Accession # :
Q07889, a.a. 564-1049
Application : 
Inhibitor Screening, Bindling Assays
Storage : 
Stable for 12 months at -80°C, Avoid freeze/thaw cycles
Reference : 
Hillig, R.C., et al., Proc Natl Acad Sci U S A. 2019;116(7):2551-2560.
Hodges, T.R., et al., J Med Chem. 2018;61(19):8875-8894.

Ordering Information

Product Cat.No. Purity Storage PKG Size Price(US$)  
Recombinant Human SOS1 NU03048-1 95 % or more (SDS-PAGE) -80°C 100 µg 325.00 Buy
Recombinant Human SOS1 NU03048-2 95 % or more (SDS-PAGE) -80°C 1 mg 1,650.00 Buy