Nacalai USA - Innovations for Life Sciences

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Nerve Organoid™ A-Chip / B-Chip

3D Nerve on a Chip / Starting the Neurorevolution

Jiksak Bioengineering develops research tools and treatments for neurological diseases, with a focus on peripheral nerve disorders. Jiksak means ”axon” in Japanese and our technology revolves around the axon.

Our Core Technologies

Nerve Organoids™

Nerve Organoids™ consist of iPS-derived nerves in a microfluidics device. The nerves formed are very similar to in vivo nerves, with long axons extending from the cell body. Nerve Organoids are used for drug screening and mechanistic studies to discover genes underlying neurological diseases. See our papers for research applications of this technology! 

Nerve Organoid™ features

  • Structurally separate neural cell body and axon bundle for ease of whole organoid, cellular soma, or acellular axon bundle analyses
  • Bundled axons, morphologically analogous to in vivo
  • Robust enough to be manipulated with forceps
  • Suitable for long term culture
  • Generated from differentiated human iPS cells; reproducible and highly consistent

Nerve Organoid™ Research Products

Nerve Organoid A-Chip

A-Chip conists sof 2 wells connected by a microchannel. iPSC-derived neuronal spheres are seeded into the smaller well and axons grow into the microchannel. After culturing for several weeks, the axons will self-organize into a bundle and extend into the far well. Cell body and axon bundle can be isolated separately for protein analysis, RNA extraction, and other molecular analyses.

Chip materials COP (cyclic olefin polymer; Zeon Corporation, Japan) Transparent, chemical resistant, heat resistant, low protein adsorption, low elution(US Pharmacopeia Class Ⅵ compliant)
Outer dimensions 38 mm(W) x 10 mm(D) x 9 mm(H)
Microchannel length 18.5 mm
Selling unit 8 chips/plate
Nerve Organoid B-Chip

B-Chip consists of 2 wells connected by a microchannel. The 2 wells are separated by a wall, allowing researchers to culture cells in different media in each well. iPSC-derived neuronal spheres are seeded into the smaller well and axons grow into the microchannel. During culture, axons self-organize into a bundle and extend into the far well where they branch out and expand uniformly into growth cones. B-Chips can be used to co-culture target cell types and to induce human synapse formation using our synaptogenic beads. B-chip fits 48 chips into an SBS standard 96-well plate, making it compatible with imaging systems.

Chip materials COP (cyclic olefin polymer; Zeon Corporation, Japan) Transparent, chemical resistant, heat resistant, low protein adsorption, low elution(US Pharmacopeia Class Ⅵ compliant)
Outer dimensions 17.9 mm(W) x 8.8 mm(D) x 12.4 mm(H)
Microchannel length 2.6 mm
Selling unit 48 chips/plate (96 well plate format)

 

Video - Axon elongation of Nerve Organoid

Video shot at 10X magnification and has been sped up by approximately 17x

Ordering Information

Product Cat.No. Storage PKG Size Price(US$)  
Nerve Organoid A-chip (cop/cop) JKSK_S0001A_1 Room Temp. 1 chips 110.00 Buy
Nerve Organoid A-chip (cop/cop) JKSK_S0001A_8 Room Temp. 8 chips/plate 875.00 Buy
Nerve Organoid A-chip (PDMS/Glass) JKSK_S0002A_1 Room Temp. 1 chips 110.00 Buy
Nerve Organoid A-chip (PDMS/Glass) JKSK_S0002A_8 Room Temp. 8 chips/plate 875.00 Buy
Nerve Organoid B-chip JKSK_S0001B_1 Room Temp. 1 chips 110.00 Buy
Nerve Organoid B-chip JKSK_S0001B_48 Room Temp. 48 chips/plate 5,251.00 Buy
A-chip Plate Holder JKSK_S0001AP Room Temp. 1 unit 19.00 Buy
A-chip Dummy Chip JKSK_S0001AD_1 Room Temp. 1 unit 12.00 Buy
A-chip Dummy Chip JKSK_S0001AD_5 Room Temp. 5 units 41.00 Buy
B-chip Plate Holder JKSK_S0001BP Room Temp. 1 unit 19.00 Buy
B-chip Dummy Chip JKSK_S0001BD_1 Room Temp. 1 unit 16.00 Buy
B-chip Dummy Chip JKSK_S0001BD_5 Room Temp. 5 units 59.00 Buy

These products are manufactured by Jiksak Bioengineering, Inc.