Nacalai USA - Innovations for Life Sciences

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Nerve Organoid™ A-Chip / B-Chip

3D Nerve on a Chip / Starting the Neurorevolution

Jiksak Bioengineering develops research tools and treatments for neurological diseases, with a focus on peripheral nerve disorders. Jiksak means ”axon” in Japanese and our technology revolves around the axon.

Our Core Technologies

Nerve Organoids™

Nerve Organoids™ consist of iPS-derived nerves in a microfluidics device. The nerves formed are very similar to in vivo nerves, with long axons extending from the cell body. Nerve Organoids are used for drug screening and mechanistic studies to discover genes underlying neurological diseases. See our papers for research applications of this technology! 

Nerve Organoid™ features

  • Structurally separate neural cell body and axon bundle for ease of whole organoid, cellular soma, or acellular axon bundle analyses
  • Bundled axons, morphologically analogous to in vivo
  • Robust enough to be manipulated with forceps
  • Suitable for long term culture
  • Generated from differentiated human iPS cells; reproducible and highly consistent

Nerve Organoid™ Research Products

Nerve Organoid A-Chip

A-Chip conists sof 2 wells connected by a microchannel. iPSC-derived neuronal spheres are seeded into the smaller well and axons grow into the microchannel. After culturing for several weeks, the axons will self-organize into a bundle and extend into the far well. Cell body and axon bundle can be isolated separately for protein analysis, RNA extraction, and other molecular analyses.

Chip materials COP (cyclic olefin polymer; Zeon Corporation, Japan) Transparent, chemical resistant, heat resistant, low protein adsorption, low elution(US Pharmacopeia Class Ⅵ compliant)
Outer dimensions 38 mm(W) x 10 mm(D) x 9 mm(H)
Microchannel length 18.5 mm
Selling unit 8 chips/plate
Nerve Organoid B-Chip

B-Chip consists of 2 wells connected by a microchannel. The 2 wells are separated by a wall, allowing researchers to culture cells in different media in each well. iPSC-derived neuronal spheres are seeded into the smaller well and axons grow into the microchannel. During culture, axons self-organize into a bundle and extend into the far well where they branch out and expand uniformly into growth cones. B-Chips can be used to co-culture target cell types and to induce human synapse formation using our synaptogenic beads. B-chip fits 48 chips into an SBS standard 96-well plate, making it compatible with imaging systems.

Chip materials COP (cyclic olefin polymer; Zeon Corporation, Japan) Transparent, chemical resistant, heat resistant, low protein adsorption, low elution(US Pharmacopeia Class Ⅵ compliant)
Outer dimensions 17.9 mm(W) x 8.8 mm(D) x 12.4 mm(H)
Microchannel length 2.6 mm
Selling unit 48 chips/plate (96 well plate format)

 

 

Nerve Organoid P-Chip

P-Chip is our product for academic research, although we sell to non-academic researchers, as well. This product consists of 8 PDMS inseparable chips mounted on a glass slide. Each chip consists of 2 wells connected by a microchannel. Neuronal cells of interest can be seeded into the smaller well to induce axonal growth into the microchannel. After culturing for several weeks, the axons will self-organize into a bundle and extend into the far well.

Chip materials PDMS-glass (Polydimethylsiloxane-glass)
Outer dimensions 4.0 cm (W) x 1.8 cm (D) x 1.0 mm (H)
Microchannel length 9.0 mm
Selling unit 8 chips/plate

Ordering Information

Product Storage Cat.No. PKG Size Price  
Nerve Organoid A-chip (cop/cop) Room Temp. JKSK_S0001A_1 1 chip 110.00
Buy
Nerve Organoid A-chip (cop/cop) Room Temp. JKSK_S0001A_8 8 chips/plate 875.00
Buy
Nerve Organoid A-chip (PDMS/Glass) Room Temp. JKSK_S0002A_1 1 chip 110.00
Buy
Nerve Organoid A-chip (PDMS/Glass) Room Temp. JKSK_S0002A_8 8 chips/plate 875.00
Buy
Nerve Organoid B-chip Room Temp. JKSK_S0001B_1 1 chip 110.00
Buy
Nerve Organoid B-chip Room Temp. JKSK_S0001B_48 48 chips/plate 5,251.00
Buy
A-chip Dummy Chip Room Temp. JKSK_S0001AD_1 1 unit 12.00
Buy
A-chip Dummy Chip Room Temp. JKSK_S0001AD_5 5 units 42.00
Buy
A-chip Plate Holder Room Temp. JKSK_S0001AP 1 unit 19.00
Buy
B-chip Dummy Chip Room Temp. JKSK_S0001BD_1 1 unit 16.00
Buy
B-chip Dummy Chip Room Temp. JKSK_S0001BD_5 5 units 59.00
Buy
B-chip Plate Holder Room Temp. JKSK_S0001BP 1 unit 19.00
Buy
Nerve Organoid P-chip (Stand-alone) Room Temp. JKSK_S0001U_SA 8 chips/plate 260.00
Buy
Nerve Organoid P-chip (PDMS/Glass) Room Temp. JKSK_S0001U 8 chips/plate 274.00
Buy

These products are manufactured by Jiksak Bioengineering, Inc.