COSMOSIL Cholester
Specialty for Structual Isomers / Hydrophobic interaction and planarity selectivity
COSMOSIL Cholester is a new silica based RP column which employs a cholestery bonded phase. Cholester provides enhanced selectivity over traditional C18 materials and greater performance in separating isomers or other closely related compounds. Cholester is ideal for method development and serves as an excellent alternative to traditional C18 columns.
| COSMOSIL Cholester | |||
|---|---|---|---|
| Silicagel | high purity porous spherical silica | ||
| Average particle size | 2.5µm | 3µm | 5µm |
| Average pore size | approx. 130Å | approx. 120Å | approx. 120Å |
| Specific surface area | approx. 330m2/g | approx. 300m2/g | approx. 300m2/g |
| Stationary phase | Monomeric Cholesteryl group | Monomeric Cholesteryl group | Monomeric Cholesteryl group |
| End capping treatment | near-perfect treatment | near-perfect treatment | near-perfect treatment |
| Carbon content | approx. 21% | - | approx. 20% |
Basic Nature
Separation of Alkylbenzene (comparison with Hydrophobicity)
Cholester provides the same hydrophobicity as ODS and C30 columns.
Planarity Selectivity (Planarity : o-Terphenyl < Triphenylene)
Cholester shows greater planarity selectivity.
Application: Aryl Halides
Characteristics of separation
Aryl Halides (Relative strengths of nucleophiles : Methyl < Chlorine < Bromine)
Cholester is more selective for Aryl Halides.
Planarity Selectivity
Planarity Selectivity (Planarity : o-Terphenyl < Triphenylene)
Cholester shows greater planarity selectivity.
Application: Steroids
Steroids like D Vitamins
Cholesteryl bonded groups are very rigid structures and offer improved separation of compounds that are difficult to analyze with alkyl group bonded materials.
Application: Diasteromers
Diasteromers like Stilbenes
Cholester offers improved resolution of geometric isomers.
Application: Position isomers
Position isomers like Chloroacetophenones and Terphenyls
Generally isomers of disubstituted benzene are difficult to separate with C18 because their structual and polar characteristics are veryb similar. In these cases COSMOSIL Cholester works very well.
Application: Geometric isomers
COSMOSIL Cholester offers improved resolution of geometric isomers.
Ordering Information
Analytical Column (Particle Size : 2.5 µm)
| Product | Cat.No. | End-Fitting | Quantity | Price(US$) | |
|---|---|---|---|---|---|
| COSMOSIL 2.5 Cholester Packed Column, 2.0 mm I.D. x 50 mm | 09000-01 | Waters type | 1 pkg | 745.00 | Buy |
| COSMOSIL 2.5 Cholester Packed Column, 2.0 mm I.D. x 75 mm | 09047-11 | Waters type | 1 pkg | 745.00 | Buy |
| COSMOSIL 2.5 Cholester Packed Column, 2.0 mm I.D. x 100 mm | 09048-01 | Waters type | 1 pkg | 745.00 | Buy |
| COSMOSIL 2.5 Cholester Packed Column, 3.0 mm I.D. x 50 mm | 09049-91 | Waters type | 1 pkg | 745.00 | Buy |
| COSMOSIL 2.5 Cholester Packed Column, 3.0 mm I.D. x 75 mm | 09050-51 | Waters type | 1 pkg | 745.00 | Buy |
| COSMOSIL 2.5 Cholester Packed Column, 3.0 mm I.D. x 100 mm | 09051-41 | Waters type | 1 pkg | 745.00 | Buy |
| COSMOSIL 2.5 Cholester Packed Column, 3.0 mm I.D. x 150 mm | 07099-01 | Waters type | 1 pkg | 860.00 | Buy |
Analytical Column (Particle Size : 3 µm)
| Product | Cat.No. | End-Fitting | Quantity | Price(US$) | |
|---|---|---|---|---|---|
| COSMOSIL 3Cholester Packed Column, 4.6mmI.D. x 100mm | 19300-61 | Waters type | 1 pkg | 590.00 | Buy |
| COSMOSIL 3Cholester Packed Column, 4.6mmI.D. x 150mm | 19151-21 | Waters type | 1 pkg | 590.00 | Buy |
| COSMOSIL 3Cholester Packed Column, 4.6mmI.D. x 250mm | 19316-71 | Waters type | 1 pkg | 690.00 | Buy |
Analytical Column (Particle Size : 5 µm)
| Product | Cat.No. | End-Fitting | Quantity | Price(US$) | |
|---|---|---|---|---|---|
| COSMOSIL Cholester Packed Column, 1.0 mm I.D. x 150 mm | 05968-71 | Waters type | 1 pkg | 475.00 | Buy |
| COSMOSIL Cholester Packed Column, 1.0 mm I.D. x 250 mm | 05969-61 | Waters type | 1 pkg | 515.00 | Buy |
| COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 30 mm | 08565-51 | Waters type | 1 pkg | 475.00 | Buy |
| COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 50 mm | 06352-91 | Waters type | 1 pkg | 535.00 | Buy |
| COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 100 mm | 06948-01 | Waters type | 1 pkg | 505.00 | Buy |
| COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 150 mm | 05971-11 | Waters type | 1 pkg | 475.00 | Buy |
| COSMOSIL Cholester Packed Column, 2.0 mm I.D. x 250 mm | 05972-01 | Waters type | 1 pkg | 515.00 | Buy |
| COSMOSIL Cholester Packed Column, 3.0 mm I.D. x 100 mm | 15892-41 | Waters type | 1 pkg | 505.00 | Buy |
| COSMOSIL Cholester Packed Column, 3.0 mm I.D. x 150 mm | 05973-91 | Waters type | 1 pkg | 475.00 | Buy |
| COSMOSIL Cholester Packed Column, 3.0 mm I.D. x 250 mm | 05974-81 | Waters type | 1 pkg | 515.00 | Buy |
| COSMOSIL Cholester Packed Column, 4.6 mm I.D. x 50 mm | 06359-21 | Waters type | 1 pkg | 535.00 | Buy |
| COSMOSIL Cholester Packed Column, 4.6 mm I.D. x 100 mm | 06591-61 | Waters type | 1 pkg | 490.00 | Buy |
| COSMOSIL Cholester Packed Column, 4.6 mm I.D. x 150 mm | 05976-61 | Waters type | 1 pkg | 490.00 | Buy |
| COSMOSIL Cholester Packed Column (3 Lots Set), 4.6 mm I.D. x 150 mm | 07970-03 | Waters type | 3 pkg | 1,420.00 | Buy |
| COSMOSIL Cholester Packed Column, 4.6 mm I.D. x 250 mm | 05977-51 | Waters type | 1 pkg | 515.00 | Buy |
Guard Cartridge (Particle Size : 5 µm)
| Product | Cat.No. | End-Fitting | Quantity | Price(US$) | |
|---|---|---|---|---|---|
| COSMOSIL Cholester Guard Cartridge, 4.6 mm I.D. x 10 mm, 2 pieces | 19183-24 | Waters type | 1 pkg | 220.00 | Buy |
| COSMOSIL Guard Cartridge Holder, 4.6 mm I.D. | 38009-79 | Waters type | 1 pkg | 275.00 | Buy |
Guard Column (Particle Size : 5 µm)
| Product | Cat.No. | End-Fitting | Quantity | Price(US$) | |
|---|---|---|---|---|---|
| COSMOSIL Cholester Guard Column, 4.6 mm I.D. x 10 mm | 05975-71 | Waters type | 1 pkg | 265.00 | Buy |
| COSMOSIL Cholester Guard Column, 10.0 mm I.D. x 20 mm | 05978-41 | Waters type | 1 pkg | 475.00 | Buy |
| COSMOSIL Cholester Guard Column, 20.0 mm I.D. x 20 mm | 05980-91 | Waters type | 1 pkg | 1,050.00 | Buy |
| COSMOSIL Cholester Guard Column, 20.0 mm I.D. x 50 mm | 05981-81 | Waters type | 1 pkg | 1,365.00 | Buy |
| COSMOSIL Cholester Guard Column, 28.0 mm I.D. x 50 mm | 05983-61 | Waters type | 1 pkg | 3,455.00 | Buy |
Preparative Column (Particle Size : 5 µm)
| Product | Cat.No. | End-Fitting | Quantity | Price(US$) | |
|---|---|---|---|---|---|
| COSMOSIL Cholester Packed Column, 10.0 mm I.D. x 100 mm | 16591-51 | Waters type | 1 pkg | 950.00 | Buy |
| COSMOSIL Cholester Packed Column, 10.0 mm I.D. x 150 mm | 08011-91 | Waters type | 1 pkg | 1,000.00 | Buy |
| COSMOSIL Cholester Packed Column, 10.0 mm I.D. x 250 mm | 05979-31 | Waters type | 1 pkg | 1,270.00 | Buy |
| COSMOSIL Cholester Packed Column, 10.0 mm I.D. x 100 mm | 15995-01 | Waters type | 1 pkg | 1,905.00 | Buy |
| COSMOSIL Cholester Packed Column, 20.0 mm I.D. x 150 mm | 06088-71 | Waters type | 1 pkg | 2,005.00 | Buy |
| COSMOSIL Cholester Packed Column, 20.0 mm I.D. x 250 mm | 05982-71 | Waters type | 1 pkg | 2,540.00 | Buy |
| COSMOSIL Cholester Packed Column, 28.0 mm I.D. x 250 mm | 05985-41 | Waters type | 1 pkg | 5,785.00 | Buy |